DNA Recognition by Eucaryotic Transcription Factors


  • Homeodomain proteins are involved in the development of many eucaryotic organisms
  • Homebox, a DNA sequence of ~ 180 base pairs within the coding region of certain genes

  • - first discovered in Drosophila
    - homeotic transformations

  • Monomers of homeodomain proteins bind to DNA through a helix-turn-helix motif





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