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Multiple
Sequence Alignment of MLH1 protein. -
To do Multiple Sequence Alignment in Biology Workbench
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1. Add MLH1_Human
protein to the Biology Workbench. Predict its secondary structure
by GOR4.
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2. Do a homology
searching of MLH1_Human in Genpept Full Release Database. Import
MLH1-like protein of C. elegans, S. cerevisiae, D. melanogaster,
R. norvegicus and M. musculus to your workbench. Run CLUSTALW to
get multiple sequence alignment for these six proteins. |
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3. Perform BOXSHADE
program to get a color-coded plot for the results of question 2.
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4. Draw rooted
phylogenetic tree for these proteins.
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