Assignment
6
Multiple
Sequence Alignment of MLH1 protein.
1. Add MLH1_Human protein to the Biology Workbench. Predict its secondary structure by GOR4.
Ans : Here
2. Do a homology searching of MLH1_Human in Genpept Full Release Database.
Import MLH1-like protein of C. elegans, S. cerevisiae, D. melanogaster, R.
norvegicus and M. musculus to your workbench. Run CLUSTALW to get multiple
sequence alignment for these six proteins.
Ans : Here
3. Perform BOXSHADE program to get a color-coded plot for the results of question
2.
Ans : Here
4. Draw rooted phylogenetic tree for these proteins.