Fasta label (*)	Workbench label
GENPEPT:1724118	Rattus norvegicus mismatch repair protein (MLH1) mRNA, complete
GENPEPT:3192877	Drosophila melanogaster mutL homolog (Mlh1) gene, complete cds_
GENPEPT:7595954	Mus musculus MutL homolog 1 protein (MLH1) mRNA, complete cds.
GENPEPT:460627	Saccharomyces cerevisiae DNA mismatch repair (MLH1) gene, complete
MLH1_HUMAN	DNA MISMATCH REPAIR PROTEIN MLH1 (MUTL PROTEIN HOMOLOG 1) [Homo sapiens (Human)]
GENPEPT:3880333	Caenorhabditis elegans cosmid T28A8, complete sequence_

(*) Clustalw cuts off Fasta labels after the first space (e.g. ">abc def" becomes ">abc").

Sequence alignment

Consensus key (see documentation for details)
* - single, fully conserved residue
: - conservation of strong groups
. - conservation of weak groups
  - no consensus


CLUSTAL W (1.81) multiple sequence alignment


GENPEPT_7595954      -----------------MAFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAK
GENPEPT_1724118      -----------------MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMTENCLDAK
MLH1_HUMAN           -----------------MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAK
GENPEPT_3192877      ---------------MAEYLQPGVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQ
GENPEPT_460627       --------------------MSLRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDAN
GENPEPT_3880333      MWHCGYRTRNCDEFSKIEFSLMGLIQRLPQDVVNRMAAGEVLARPCNAIKELVENSLDAG
                                             *: *   ***::****::  * **:**: **.:** 

GENPEPT_7595954      STNIQVVVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQTFEDLASISTYGFRGEA
GENPEPT_1724118      STNIQVIVREGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQTFEDLAMISTYGFRGEA
MLH1_HUMAN           STSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEA
GENPEPT_3192877      STHIQVQVKAGGLKLLQIQDNGTGIRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEA
GENPEPT_460627       ATMIDILVKEGGIKVLQITDNGSGINKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEA
GENPEPT_3880333      ATEIMVNMQNGGLKLLQVSDNGKGIEREDFALVCERFATSKLQKFEDLMHMKTYGFRGEA
                     :* * : :: **:*::*: ***.**.: *: ::****:****  ****  : *:******

GENPEPT_7595954      LASISHVAHVTITTKTADGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNIITRR
GENPEPT_1724118      LASISHVAHVTITTKTADGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNIITRK
MLH1_HUMAN           LASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRR
GENPEPT_3192877      LASISHVAHLSIQTKTAKEKCGYKATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRR
GENPEPT_460627       LASISHVARVTVTTKVKEDRCAWRVSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRL
GENPEPT_3880333      LASLSHVAKVNIVSKRADAKCAYQANFLDGKMTADTKPAAGKNGTCITATDLFYNLPTRR
                     ***:****::.: :*  . :*.::..: :**:   .** **::** *   ***:*:  * 

GENPEPT_7595954      KALKNPSEEYGKILEVVGRYSIHNSGISFSVKKQGETVSDVRTLPNATTVDNIRSIFGNA
GENPEPT_1724118      KALKNPSEEYGKILEVVGRYSIHNSGISFSVKKQGETVSDVRTLPNATTVDNIRSIFGNA
MLH1_HUMAN           KALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNA
GENPEPT_3192877      QALRSPAEEFQRLSEVLARYAVHNPRVGFTLRKQGDAQPALRTPVASSRSENIRIIYGAA
GENPEPT_460627       RALRSHNDEYSKILDVVGRYAIHSKDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFNKS
GENPEPT_3880333      NKMTTHGEEAKMVNDTLLRFAIHRPDVSFALRQ--NQAGDFRTKGDGNFRDVVCNLLGRD
                     . : .  :*   : :.: *:::*   :.*: ::  :    . .    .  : :  : .  

GENPEPT_7595954      VSRELIEVG-CEDKTLAFK-MNGYISNANYSVKKCI----------FLLFINHRLVESAA
GENPEPT_1724118      VSRELIEVG-CEDKTLAFK-MNGYISNANYSVKKCI----------FLLFINHRLVESAA
MLH1_HUMAN           VSRELIEIG-CEDKTLAFK-MNGYISNANYSVKKCI----------FLLFINHRLVESTS
GENPEPT_3192877      ISKELLEFS-HRDEVYKFE-AECLITQVNYSAKKCQ----------MLLFINQRLVESTA
GENPEPT_460627       VASNLITFHISKVEDLNLESVDGKVCNLNFISKKSIS---------LIFFINNRLVTCDL
GENPEPT_3880333      VADTILPLS-LNSTRLKFT-FTGHISKPIASATAAIAQNRKTSRSFFSVFINGRSVRCDI
                     ::  :: .   .     :      : :     . .           : .*** * * .  

GENPEPT_7595954      LRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILQRVQQHIE
GENPEPT_1724118      LKKAIEAVYAAYLPKNTHPFLYLILEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIE
MLH1_HUMAN           LRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIE
GENPEPT_3192877      LRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVHFLYQEEIVDSIKQQVE
GENPEPT_460627       LRRALNSVYSNYLPKGFRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKIANQLH
GENPEPT_3880333      LKHPIDEVLG--ARQLHAQFCALHLQIDETRIDVNVHPTKNSVIFLEKEEIIEEIRAYFE
                     *: .:: : .    :    *  : : :    :********..* ** ::.*:: :   ..

GENPEPT_7595954      SKLLGSNSSRMYFTQTLLPGLAG------PSGEAARPTTGVASSSTSGSGDKVYAYQMVR
GENPEPT_1724118      SKLLGSNSSRMYFTQTLLPGLAG------PSGEAVKSTTGIASSSTSGSGDKVHAYQMVR
MLH1_HUMAN           SKLLGSNSSRMYFTQTLLPGLAG------PSGEMVKSTTSLTSSSTSGSSDKVYAHQMVR
GENPEPT_3192877      ARLLGSNATRTFYKQLRLPGAP-----------------DLDETQLADKTQRIYPKEMVR
GENPEPT_460627       AELSAIDTSRTFKASSISTNKPESLIPFNDTIESDRNRKSLRQAQVVENSYTTANSQLRK
GENPEPT_3880333      KVIGEIFGFEALDVEKPEEEQPD--------IENLVMIPMSQSLKSIEAIRKPDTKPEFK
                       :      .    .      .                    . .              :

GENPEPT_7595954      TDSRDQKLDAFLQPVSSLVPSQPQDPAPVRGARTEGSPERATREDEEMLALPAPAEAAAE
GENPEPT_1724118      TDSRDQKLDAFMQPVSRRLPSQPQD--PVPGNRTEGSPEKAMQKDQEISELPAPMEAAAD
MLH1_HUMAN           TDSREQKLDAFLQPLSKPLSSQPQ--AIVTEDKTDISSGRARQQDEEMLELPAPAEVAAK
GENPEPT_3192877      TDSTEQKLDKFLAPLVK-------------------------------------------
GENPEPT_460627       AKRQENKLVRIDASQAKITSFLSSS--QQFNFEGSSTKRQLSEPKVTNVSHSQEAEKLTL
GENPEPT_3880333      SSPSAWKSDKKRVDYMEVRTDAKERKIDEFVTRGGAVGPTTSNDDIFGGSGILKRARTED
                     :.    *                                                     

GENPEPT_7595954      SENLERESLMETSDAAQKAAPTSSPGSSRKRHREDSDVEMVENASGKEMTAACYPRRRII
GENPEPT_1724118      SASLERESVIGASEVVAPQRHPSSPGSSRKRHPEDSDVEMMENDSRKEMTAACYPRRRII
MLH1_HUMAN           NQSLEGDTTKGTSEMSEKRGPTSS--NPRKRHREDSDVEMVEDDSRKEMTAACTPRRRII
GENPEPT_3192877      ----------------SDSGVSSSSSQEASRLPEES------------FRVTAAKKSREV
GENPEPT_460627       NESEQPRDANTINDNDLKDQPKKKQKLGDYKVPSIADDEKNALPISKDGYIRVPKERVNV
GENPEPT_3880333      STGGEKEPEDLNTDFDDVSMVSLVSTADGRRLNESQD-----LGEDDDVDFEYGKTHREF
                                                   :  .                         .

GENPEPT_7595954      NLTSVLSLQEEISERCHETLREILRNHSFVGCVNPQW--ALAQHQTKLYLLNTTKLSEEL
GENPEPT_1724118      NLTSVLSLQEEINDRGHETLREMLRNHTFVGCVNPQW--ALAQHQTKLYLLNTTKLSEEL
MLH1_HUMAN           NLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQW--ALAQHQTKLYLLNTTKLSEEL
GENPEPT_3192877      RLSSVLDMRKRVERQCSVQLRSTLKNLVYVGCVDERR--ALFQHETRLYMCNTRSFSEEL
GENPEPT_460627       NLTSIKKLREKVDDSIHRELTDIFANLNYVGVVDEERRLAAIQHDLKLFLIDYGSVCYEL
GENPEPT_3880333      HFESIEVLRKEIIANSSQSLREMFKTSTFVGSINVKQ--VLIQFGTSLYHLDFSTVLREF
                     .: *:  :::.:       * . : .  :** :: .   .  *.   *:  :  ..  *:

GENPEPT_7595954      FYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEDDGPKEGLA-----EYIVEF
GENPEPT_1724118      FYQILIYDFANFGVLRLPEPAPLFDFAMLALDSPESGWTEEDGPKEGLA-----EYIVEF
MLH1_HUMAN           FYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLA-----EYIVEF
GENPEPT_3192877      FYQRMIYEFQNCSEITICPPLPLKELLILSLESRAAGWTPEDEDKAELA-----DGAADI
GENPEPT_460627       FYQIGLTDFANFGKINLQSTNVSDDIVLYNLLSEFDELN-DDASK---------EKIISK
GENPEPT_3880333      FYQISVFSFGNYGSYRLDE-EPPAIIEILELLGELSTREPNYAAFEVFANVENRFAAEKL
                     ***  : .* * .   :        : :  * .       :                 . 

GENPEPT_7595954      LKKKAEMLADYFSVEIDEEGN--------LIGLPLLIDSYVPPLEGLPIFILRLATEVNW
GENPEPT_1724118      LKKKAKMLADYFSVEIDEEGN--------LIGLPLLIDSYVPPLEGLPIFILRLATEVNW
MLH1_HUMAN           LKKKAEMLADYFSLEIDEEGN--------LIGLPLLIDNYVPPLEGLPIFILRLATEVNW
GENPEPT_3192877      LLKKAPIMREYFGLRISEDGM--------LESLPSLLHQHRPCVAHLPVYLLRLATEVDW
GENPEPT_460627       IWDMSSMLNEYYSIELVNDGLDNDLKSVKLKSLPLLLKGYIPSLVKLPFFIYRLGKEVDW
GENPEPT_3880333      LAEHADLLHDYFAIKLDQLENGR----LHITEIPSLVHYFVPQLEKLPFLIATLVLNVDY
                     : . : :: :*:.:.: :           :  :* *:. . * :  **. :  *  :*::

GENPEPT_7595954      DEEKECFESLSKECAMFYSIRKQYILEESTLSGQQSDMPGSTSKPWKWT--VEHIIYKAF
GENPEPT_1724118      DEE-ECFESLSKECAVFYSIRKQYILEESALSGQQSDMPGSPSKPWKWT--VEHIIYKAF
MLH1_HUMAN           DEEKECFES


MLH1_HUMAN           DEEKECFES