Sequence feature view of the region: gi|463988:22-2292

LOCUS       U07343       2271 bp    mRNA            PRI       29-NOV-1995
DEFINITION  Gene from: Human DNA mismatch repair protein homolog (hMLH1) mRNA,
            complete cds.
ACCESSION   U07343
VERSION     U07343.1
KEYWORDS    .
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 22 to 2292)
  AUTHORS   Bronner,C.E., Baker,S.M., Morrison,P.T., Warren,G., Smith,L.G.,
            Lescoe,M.K., Kane,M., Earibino,C., Lipford,J., Linblom,A.,
            Tannergard,P., Bollag,R.J., Godwin,A.R., Ward,D.C.,
            Nordenskjold,M., Fishel,R., Kolodner,R.D. and Liskay,R.M.
  TITLE     Mutation in the DNA mismatch repair gene homologue hMLH1 is
            associated with hereditary non-polyposis colon cancer
  JOURNAL   Nature 368 (6468), 258-261 (1994)
  MEDLINE   94195398
REFERENCE   2  (bases 22 to 2292)
  AUTHORS   Morrison,P.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAR-1994) Paul T. Morrison, Molecular Biology Core
            Facility, Dana-Farber Cancer Institute, 44 Binney Street, Boston,
            MA 002115, USA
FEATURES             Location/Qualifiers
     gene            <1..>2271
     gene            1..2271
                     /gene="hMLH1"
     CDS             1..2271
                     /gene="hMLH1"
                     /note="homolog of S. cerevisiae PMS1 (Swiss-Prot Accession
                     Number P14242), S. cerevisiae MLH1 (GenBank Accession
                     Number U07187), E. coli MUTL (Swiss-Prot Accession Number
                     P23367), Salmonella typhimurium MUTL (Swiss-Prot Accession
                     Number P14161) and Streptococcus pneumoniae (Swiss-Prot
                     Accession Number P14160)"
                     /codon_start=1
                     /product="hMLH1"
                     /protein_id="AAC50285.1"
                     /db_xref="GI:463989"
                     /translation="MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKS
                     TSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGE
                     ALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIA
                     TRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRS
                     IFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAI
                     ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKL
                     LGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQK
                     LDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGD
                     TTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLS
                     LQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIY
                     DFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLAD
                     YFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM
                     FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNI
                     LQLANLPDLYKVFERC"
BASE COUNT      660 a    501 c    554 g    556 t
ORIGIN      
        1 atgtcgttcg tggcaggggt tattcggcgg ctggacgaga cagtggtgaa ccgcatcgcg
       61 gcgggggaag ttatccagcg gccagctaat gctatcaaag agatgattga gaactgttta
      121 gatgcaaaat ccacaagtat tcaagtgatt gttaaagagg gaggcctgaa gttgattcag
      181 atccaagaca atggcaccgg gatcaggaaa gaagatctgg atattgtatg tgaaaggttc
      241 actactagta aactgcagtc ctttgaggat ttagccagta tttctaccta tggctttcga
      301 ggtgaggctt tggccagcat aagccatgtg gctcatgtta ctattacaac gaaaacagct
      361 gatggaaagt gtgcatacag agcaagttac tcagatggaa aactgaaagc ccctcctaaa
      421 ccatgtgctg gcaatcaagg gacccagatc acggtggagg acctttttta caacatagcc
      481 acgaggagaa aagctttaaa aaatccaagt gaagaatatg ggaaaatttt ggaagttgtt
      541 ggcaggtatt cagtacacaa tgcaggcatt agtttctcag ttaaaaaaca aggagagaca
      601 gtagctgatg ttaggacact acccaatgcc tcaaccgtgg acaatattcg ctccatcttt
      661 ggaaatgctg ttagtcgaga actgatagaa attggatgtg aggataaaac cctagccttc
      721 aaaatgaatg gttacatatc caatgcaaac tactcagtga agaagtgcat cttcttactc
      781 ttcatcaacc atcgtctggt agaatcaact tccttgagaa aagccataga aacagtgtat
      841 gcagcctatt tgcccaaaaa cacacaccca ttcctgtacc tcagtttaga aatcagtccc
      901 cagaatgtgg atgttaatgt gcaccccaca aagcatgaag ttcacttcct gcacgaggag
      961 agcatcctgg agcgggtgca gcagcacatc gagagcaagc tcctgggctc caattcctcc
     1021 aggatgtact tcacccagac tttgctacca ggacttgctg gcccctctgg ggagatggtt
     1081 aaatccacaa caagtctgac ctcgtcttct acttctggaa gtagtgataa ggtctatgcc
     1141 caccagatgg ttcgtacaga ttcccgggaa cagaagcttg atgcatttct gcagcctctg
     1201 agcaaacccc tgtccagtca gccccaggcc attgtcacag aggataagac agatatttct
     1261 agtggcaggg ctaggcagca agatgaggag atgcttgaac tcccagcccc tgctgaagtg
     1321 gctgccaaaa atcagagctt ggagggggat acaacaaagg ggacttcaga aatgtcagag
     1381 aagagaggac ctacttccag caaccccaga aagagacatc gggaagattc tgatgtggaa
     1441 atggtggaag atgattcccg aaaggaaatg actgcagctt gtaccccccg gagaaggatc
     1501 attaacctca ctagtgtttt gagtctccag gaagaaatta atgagcaggg acatgaggtt
     1561 ctccgggaga tgttgcataa ccactccttc gtgggctgtg tgaatcctca gtgggccttg
     1621 gcacagcatc aaaccaagtt ataccttctc aacaccacca agcttagtga agaactgttc
     1681 taccagatac tcatttatga ttttgccaat tttggtgttc tcaggttatc ggagccagca
     1741 ccgctctttg accttgccat gcttgcctta gatagtccag agagtggctg gacagaggaa
     1801 gatggtccca aagaaggact tgctgaatac attgttgagt ttctgaagaa gaaggctgag
     1861 atgcttgcag actatttctc tttggaaatt gatgaggaag ggaacctgat tggattaccc
     1921 cttctgattg acaactatgt gccccctttg gagggactgc ctatcttcat tcttcgacta
     1981 gccactgagg tgaattggga cgaagaaaag gaatgttttg aaagcctcag taaagaatgc
     2041 gctatgttct attccatccg gaagcagtac atatctgagg agtcgaccct ctcaggccag
     2101 cagagtgaag tgcctggctc cattccaaac tcctggaagt ggactgtgga acacattgtc
     2161 tataaagcct tgcgctcaca cattctgcct cctaaacatt tcacagaaga tggaaatatc
     2221 ctgcagcttg ctaacctgcc tgatctatac aaagtctttg agaggtgtta a
//