The most commonly used toxic moieties are derived from either bacteria[e.g. Pseudomonas exotoxin(PE) or diptheria toxin(DT)], or plants(e.g. abrin or ricin).
Toxic Moiety
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The most commonly used toxic moieties are derived from either bacteria[e.g. Pseudomonas exotoxin(PE) or diptheria toxin(DT)], or plants(e.g. abrin or ricin). |
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Both types of toxins kill cells by inhibiting protein synthesis. |
Plant toxins damage 28S rRNA, Bacterial toxins inactivate EF-2
Fig. Mode of action of ITs
