| |
The topology of the native state largely determines the overall features
of protein-folding reactions and that non-native interactions have a relatively
minor role.Three independent lines
of investigation indicate that protein-folding rates and mechanisms
are largely determined by a protein's topology rather than its inter-atomic
interactions.
The topology of a
protein's native state appears to determine the major features of its folding
free-energy landscape. Both protein structures and protein-folding mechanisms
can be predicted.
|
|
