ONCOGENES
|
|
| Genes for growth factors or their receptors: |
| PDGF |
Codes for platelet-derived growth factor; involved in glioma |
| erb-B |
Codes for epidermal growth factor receptor; involved in glioblastoma and
breast cancer |
| erb-B2 |
Codes for a growth factor receptor; involved in breast, salivary gland and
ovarian cancers |
| Genes for cytoplasmic relays in stimulatory signaling
pathways |
| Ki-ras |
Involved in lung, ovarian, colon, and pancreatic cancers |
| N-ras |
Involved in leukemias |
| Genes for transcription factors that activate
growth-promoting genes |
| c-myc |
Involved in leukemias and breast, stomach and lung cancers |
| N-myc |
Involved in neuroblastoma and glioblastoma |
| L-myc |
Involved in lung cancer |
| Genes for other kinds of molecules |
| Bcl-2 |
Codes for a protein that normally blocks cell suicide; follicular B cell
lymphoma |
| Bcl-1 |
Codes for cyclin D1, a stimulatory component of cell cycle clock; breast,
head and neck cancer |
| MDM2 |
Codes for antagonist of the p53 tumor suppressor protein; sarcomas |
TUMOR SUPPRESSOR GENES
|
| Cytoplasmic Protein Genes |
| APC |
invovled in colon and stomach cancers |
| DPC4 |
codes for relay molecule in signaling pathway that inhibits cell division;
pancreatic cancer |
| NF-1 |
codes for protein inhibitor of stimulatory (Ras) protein |
| NF-2 |
involved in meningioma, ependymona, schwannoma |
| Nuclear Protein Genes |
|
| MTS1 |
Codes for p16 protein, a braking component of cell cycle clock; involved
in many cancers |
| RB |
Codes for pRB protein, a master brake of cell cycle; involved in many
cancers |
| p53 |
Codes for p53 protein, which can halt cell division and induce
apoptosis |