Search the OWL Database

The OWL database is a non-redundant protein sequence database produced from the following source databases:

• SWISSPROT Bairoch, A. & Boeckman, B. (1991)
• PIR(1-3) Sidman, K., George, D., Barker, W. * Hunt, L. (1988)
• GenBank translations Benson, D, Lipman, D., & Ostell, J. (1993)
• NRL-3D Pattabiraman N., Lowrey, A., Gaber, B., George,D.G. & Barker,W.C. (1989)

The Web version derived from OWL has hot links to the following Databases:

• PIR(1-3) - The Protein Identification Resource
• GenBank - DNA Sequence Database
• EMBL - The European Molecular Biology DNA Sequence Database
• DDBJ - The DNA Data Bank of Japan.
• PDB - The Protein Databank (3D structures)
• EC-Enzyme - The EC Enzyme Classification Database
• PROSITE - A Dictionary of Protein Sites and Patterns
• OMIM - Online Mendelain Inheritance in Man
• SWISS-2DPAGE - Two-dimensional Polyacrylamide Gel Electrophoresis Database
• REBASE - The Restriction Enzyme Database
• Refbase - A Protein Sequence Citation Database

Many of which have links among themselves and to other databases.

No two sequences in this database are exactly the same and no two sequences show only `trivial' differences (see the first reference for the definition of triviality.)

Searching:

You may search this database using booleans (and, or, not), nested booleans, wildcards (*), and phrase searches (" ").

For Example: A search for -

kinase and 3d

will pull out all the kinases whose 3d structure is known.

A search for -

kinase and 3d not mouse

will pull out all the kinases whose 3d structure is known from all organisms except the mouse.

Experimental: If you're feeling a bit more ambitious you can also do nested booleans - just use parenthesis to define the different parts of your search:

kinase and (serine or tyrosine) not threonine

Reference:

Bleasby, A.J. and Wootton, J.C. (1990) Prot. Engng. 3(3):153-9

Note: Some of these database entries contain images - if you have a very slow connection to the internet (like working over a phone line with SLIP or PPP), you might want to turn your Display Inline Images option off.