Search genes associated with colon cancer in human genome.

MLH1 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS.

How many loci will you find if you search locus link for human in Genebank?

" 21 locis "

Give the locus ID and position of MLH1.

" ID : 4292 / position : 3p21.3 "

Find the %ID of nucleotide sequence for its possible orthologs in mouse.

" 90.5% "

Find the total number of mutations of MLH1 reported in human gene mutation database.

" 147 mutations "

Give the DNA sequence of MLH1.

" MLH1 " ( MLH1 in NCBI )

Give the DNA sequence of E. coli mismatch repair gene mutS.

" mutS " ( mutS in NCBI )