A structural analog of hypoxanthine that inhibits xanthine oxidase.
Cause accumulation of hypoxanthine and xanthine, more soluble and readily excreted.
Hyperuricemia / Gout
Chronic elevation of blood uric acid levels well beyond normal limits.
A metabolic disorder of purine catabolism.
Type I
£»Elevated activity of PRPP synthetase
Type II
£»PRPP amidotransferase: Mutation and loss of feedback inhibition by purine nucleotide.
Type III
£»Deficiency of HGPRT and cause acumulation of PPRT
Allopurinol
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A structural analog of hypoxanthine that inhibits xanthine oxidase. Cause accumulation of hypoxanthine and xanthine, more soluble and readily excreted. |