1. Make a protein structure model of MLH1 based on the protein you find in assignment 7. Show their pairwise alignment.

Query: 25  IQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSK 84
             RPA   KE  EN LDA  T I      GG KLI I DNG GI K  L           
Sbjct: 1   VERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALAL------A 54


Query: 85  LQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAG 144
             S  DL  I   GFRGEALASIS V   T T  TA    A                   
Sbjct: 55  IASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAW------------------ 96


Query: 145 NQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADV 204
            Q    TV        T    L     E   I E   R               G  V   
Sbjct: 97  -QAYAVTVKPAAHPVGTTLEVLDTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQY 155


Query: 205 RTLPNASTVD-NIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKC--IFLLF 261
           R  P           I G A       I      L     G     N        I    
Sbjct: 156 RAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLT--LRGWVADPNHTTPALAEIQYCY 213


Query: 262 INHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVH 308
            N R         AI       L     P   L LEI P  V   VH
Sbjct: 214 VNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVSRLVH 260

2. How large is the fragment of MLH1 possible to be modeled?
Ans: 125 residues

3. Show three rasmol pictures of your model of MLH1