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LOCUS HSU07343 2484 bp mRNA PRI 29-NOV-1995
DEFINITION Human DNA mismatch repair protein homolog (hMLH1) mRNA, complete
cds.
ACCESSION U07343
VERSION U07343.1 GI:463988
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2484)
AUTHORS Bronner,C.E., Baker,S.M., Morrison,P.T., Warren,G., Smith,L.G.,
Lescoe,M.K., Kane,M., Earibino,C., Lipford,J., Linblom,A.,
Tannergard,P., Bollag,R.J., Godwin,A.R., Ward,D.C.,
Nordenskjold,M., Fishel,R., Kolodner,R.D. and Liskay,R.M.
TITLE Mutation in the DNA mismatch repair gene homologue hMLH1 is
associated with hereditary non-polyposis colon cancer
JOURNAL Nature 368 (6468), 258-261 (1994)
MEDLINE 94195398
REFERENCE 2 (bases 1 to 2484)
AUTHORS Morrison,P.T.
TITLE Direct Submission
JOURNAL Submitted (02-MAR-1994) Paul T. Morrison, Molecular Biology Core
Facility, Dana-Farber Cancer Institute, 44 Binney Street, Boston,
MA 002115, USA
FEATURES Location/Qualifiers
source 1..2484
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p22-23"
gene 22..2292
/gene="hMLH1"
CDS 22..2292
/gene="hMLH1"
/note="homolog of S. cerevisiae PMS1 (Swiss-Prot Accession
Number P14242), S. cerevisiae MLH1 (GenBank Accession
Number U07187), E. coli MUTL (Swiss-Prot Accession Number
P23367), Salmonella typhimurium MUTL (Swiss-Prot Accession
Number P14161) and Streptococcus pneumoniae (Swiss-Prot
Accession Number P14160)"
/codon_start=1
/product="hMLH1"
/protein_id="AAC50285.1"
/db_xref="GI:463989"
/translation="MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKS
TSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGE
ALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIA
TRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRS
IFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAI
ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKL
LGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQK
LDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGD
TTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLS
LQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIY
DFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLAD
YFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM
FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNI
LQLANLPDLYKVFERC"
BASE COUNT 720 a 535 c 594 g 635 t
ORIGIN
1 cttggctctt ctggcgccaa aatgtcgttc gtggcagggg ttattcggcg gctggacgag
61 acagtggtga accgcatcgc ggcgggggaa gttatccagc ggccagctaa tgctatcaaa
121 gagatgattg agaactgttt agatgcaaaa tccacaagta ttcaagtgat tgttaaagag
181 ggaggcctga agttgattca gatccaagac aatggcaccg ggatcaggaa agaagatctg
241 gatattgtat gtgaaaggtt cactactagt aaactgcagt cctttgagga tttagccagt
301 atttctacct atggctttcg aggtgaggct ttggccagca taagccatgt ggctcatgtt
361 actattacaa cgaaaacagc tgatggaaag tgtgcataca gagcaagtta ctcagatgga
421 aaactgaaag cccctcctaa accatgtgct ggcaatcaag ggacccagat cacggtggag
481 gacctttttt acaacatagc cacgaggaga aaagctttaa aaaatccaag tgaagaatat
541 gggaaaattt tggaagttgt tggcaggtat tcagtacaca atgcaggcat tagtttctca
601 gttaaaaaac aaggagagac agtagctgat gttaggacac tacccaatgc ctcaaccgtg
661 gacaatattc gctccatctt tggaaatgct gttagtcgag aactgataga aattggatgt
721 gaggataaaa ccctagcctt caaaatgaat ggttacatat ccaatgcaaa ctactcagtg
781 aagaagtgca tcttcttact cttcatcaac catcgtctgg tagaatcaac ttccttgaga
841 aaagccatag aaacagtgta tgcagcctat ttgcccaaaa acacacaccc attcctgtac
901 ctcagtttag aaatcagtcc ccagaatgtg gatgttaatg tgcaccccac aaagcatgaa
961 gttcacttcc tgcacgagga gagcatcctg gagcgggtgc agcagcacat cgagagcaag
1021 ctcctgggct ccaattcctc caggatgtac ttcacccaga ctttgctacc aggacttgct
1081 ggcccctctg gggagatggt taaatccaca acaagtctga cctcgtcttc tacttctgga
1141 agtagtgata aggtctatgc ccaccagatg gttcgtacag attcccggga acagaagctt
1201 gatgcatttc tgcagcctct gagcaaaccc ctgtccagtc agccccaggc cattgtcaca
1261 gaggataaga cagatatttc tagtggcagg gctaggcagc aagatgagga gatgcttgaa
1321 ctcccagccc ctgctgaagt ggctgccaaa aatcagagct tggaggggga tacaacaaag
1381 gggacttcag aaatgtcaga gaagagagga cctacttcca gcaaccccag aaagagacat
1441 cgggaagatt ctgatgtgga aatggtggaa gatgattccc gaaaggaaat gactgcagct
1501 tgtacccccc ggagaaggat cattaacctc actagtgttt tgagtctcca ggaagaaatt
1561 aatgagcagg gacatgaggt tctccgggag atgttgcata accactcctt cgtgggctgt
1621 gtgaatcctc agtgggcctt ggcacagcat caaaccaagt tataccttct caacaccacc
1681 aagcttagtg aagaactgtt ctaccagata ctcatttatg attttgccaa ttttggtgtt
1741 ctcaggttat cggagccagc accgctcttt gaccttgcca tgcttgcctt agatagtcca
1801 gagagtggct ggacagagga agatggtccc aaagaaggac ttgctgaata cattgttgag
1861 tttctgaaga agaaggctga gatgcttgca gactatttct ctttggaaat tgatgaggaa
1921 gggaacctga ttggattacc ccttctgatt gacaactatg tgcccccttt ggagggactg
1981 cctatcttca ttcttcgact agccactgag gtgaattggg acgaagaaaa ggaatgtttt
2041 gaaagcctca gtaaagaatg cgctatgttc tattccatcc ggaagcagta catatctgag
2101 gagtcgaccc tctcaggcca gcagagtgaa gtgcctggct ccattccaaa ctcctggaag
2161 tggactgtgg aacacattgt ctataaagcc ttgcgctcac acattctgcc tcctaaacat
2221 ttcacagaag atggaaatat cctgcagctt gctaacctgc ctgatctata caaagtcttt
2281 gagaggtgtt aaatatggtt atttatgcac tgtgggatgt gttcttcttt ctctgtattc
2341 cgatacaaag tgttgtatca aagtgtgata tacaaagtgt accaacataa gtgttggtag
2401 cacttaagac ttatacttgc cttctgatag tattccttta tacacagtgg attgattata
2461 aataaataga tgtgtcttaa cata
//
