Score E
Sequences producing significant alignments: (bits) Value
gi|13878583|sp|Q9JK91|MLH1_MOUSE DNA MISMATCH REPAIR PROTEI... 1292 0.0
gi|13591989|ref|NP_112315.1| mismatch repair protein [Rattu... 1289 0.0
gi|4557757|ref|NP_000240.1| mutL homolog 1; mutL (E. coli) ... 1467 0.0
gi|466462|gb|AAA17374.1| (U07418) human homolog of E. coli ... 1466 0.0
gi|604369|gb|AAA85687.1| (U17857) hMLH1 gene product [Homo ... 1453 0.0
gi|12835158|dbj|BAB23172.1| (AK004105) putative [Mus musculus] 753 0.0
gi|13543339|gb|AAH05833.1|AAH05833 (BC005833) Similar to mu... 731 0.0
gi|7304079|gb|AAF59117.1| (AE003838) Mlh1 gene product [Dro... 615 e-175
gi|3192877|gb|AAC19117.1| (AF068257) mutL homolog [Drosophi... 608 e-173
gi|460627|gb|AAA16835.1| (U07187) Mlh1p [Saccharomyces cere... 471 e-132
gi|6323819|ref|NP_013890.1| Required for mismatch repair in... 471 e-131
gi|11280245|pir||T50317 probable DNA mismatch repair protei... 415 e-115
gi|13430732|gb|AAK25988.1|AF360278_1 (AF360278) putative ML... 384 e-105
gi|15233750|ref|NP_192653.1| MLH1 protein [Arabidopsis thal... 384 e-105
gi|7508639|pir||T25389 hypothetical protein T28A8.7 - Caeno... 375 e-103
gi|13517948|gb|AAK29067.1|AF346620_1 (AF346620) MLH1 [Trypa... 304 2e-81
gi|1465764|gb|AAC52672.1| (U60872) similar to human MLH1 on... 302 8e-81
gi|5107506|pdb|1BKN|A Chain A, Crystal Structure Of An N-Te... 207 2e-52
gi|4929884|pdb|1B62|A Chain A, Mutl Complexed With Adp 207 2e-52
gi|5542073|pdb|1B63|A Chain A, Mutl Complexed With Adpnp 207 5e-52
gi|15602769|ref|NP_245841.1| MutL [Pasteurella multocida] >... 206 1e-51
gi|15804759|ref|NP_290800.1| enzyme in methyl-directed mism... 205 1e-51
gi|16131992|ref|NP_418591.1| enzyme in methyl-directed mism... 205 1e-51
gi|16272041|ref|NP_438240.1| DNA mismatch repair protein (m... 204 2e-51
gi|15794549|ref|NP_284371.1| DNA mismatch repair protein [N... 202 1e-50
gi|14194230|gb|AAK56306.1|AF378369_2 (AF378369) DNA mismatc... 201 2e-50
gi|16120706|ref|NP_404019.1| DNA mismatch repair protein [Y... 201 2e-50
gi|15924287|ref|NP_371821.1| DNA mismatch repair protein [S... 201 2e-50
gi|15895111|ref|NP_348460.1| DNA mismatch repair enzyme, Mu... 201 3e-50
gi|7328294|emb|CAB82461.1| (AJ131755) DNA mismatch repair p... 200 4e-50
gi|15614931|ref|NP_243234.1| DNA mismatch repair protein [B... 200 5e-50
gi|15677300|ref|NP_274454.1| mismatch repair protein MutL [... 200 5e-50
gi|14577936|gb|AAK68861.1| (AF091119) HexB [Lactococcus lac... 200 5e-50
gi|15674190|ref|NP_268365.1| DNA mismatch repair protein Mu... 200 5e-50
gi|16505486|emb|CAD06836.1| (AL627283) DNA mismatch repair ... 199 6e-50
gi|15640372|ref|NP_229999.1| DNA mismatch repair protein Mu... 199 7e-50
gi|127553|sp|P14161|MUTL_SALTY DNA MISMATCH REPAIR PROTEIN ... 198 1e-49
gi|15600139|ref|NP_253633.1| DNA mismatch repair protein Mu... 194 4e-48
gi|16413914|emb|CAC96672.1| (AL596168) DNA mismatch repair ... 192 1e-47
gi|16410833|emb|CAC99482.1| (AL591979) DNA mismatch repair ... 187 4e-46
gi|15675871|ref|NP_270045.1| putative DNA mismatch repair p... 186 6e-46
gi|15893284|ref|NP_360998.1| DNA mismatch repair protein Mu... 185 1e-45
gi|15900110|ref|NP_344714.1| DNA mismatch repair protein He... 184 4e-45
gi|123083|sp|P14160|HEXB_STRPN DNA MISMATCH REPAIR PROTEIN ... 182 1e-44
gi|15617161|ref|NP_240374.1| DNA mismatch repair protein mu... 181 2e-44
gi|15964569|ref|NP_384922.1| PROBABLE DNA MISMATCH REPAIR P... 181 3e-44
gi|15888043|ref|NP_353724.1| AGR_C_1260p [Agrobacterium tum... 177 3e-43
gi|16078768|ref|NP_389587.1| mutL [Bacillus subtilis] >gi|1... 177 3e-43
gi|15642797|ref|NP_227838.1| DNA mismatch repair protein [T... 176 6e-43
gi|8928224|sp|P74925|MUTL_THEMA DNA MISMATCH REPAIR PROTEIN... 176 6e-43
gi|15789473|ref|NP_279297.1| DNA mismatch repair protein; M... 175 1e-42
gi|13476839|ref|NP_108408.1| DNA mismatch repair protein Mu... 174 2e-42
gi|15604708|ref|NP_221226.1| DNA MISMATCH REPAIR PROTEIN MU... 174 3e-42
gi|16124948|ref|NP_419512.1| DNA mismatch repair protein Mu... 173 5e-42
gi|15837362|ref|NP_298050.1| DNA mismatch repair protein Mu... 172 9e-42
gi|15594556|ref|NP_212345.1| DNA mismatch repair protein (m... 165 1e-39
gi|4505913|ref|NP_000526.1| PMS2; postmeiotic segregation i... 164 2e-39
gi|557470|gb|AAA50390.1| (U14658) similar to S. cerevisiae ... 164 2e-39
gi|14748053|ref|XP_037287.1| hypothetical protein XP_037287... 163 5e-39
gi|15606703|ref|NP_214083.1| DNA mismatch repair protein Mu... 161 2e-38
gi|13446680|gb|AAK26449.1|AF285636_1 (AF285636) putative mi... 159 8e-38
gi|15605304|ref|NP_220090.1| DNA Mismatch Repair [Chlamydia... 159 1e-37
gi|3914082|sp|P70754|MUTL_AQUPY DNA MISMATCH REPAIR PROTEIN... 156 7e-37
gi|1709684|sp|P54280|PMS1_SCHPO DNA MISMATCH REPAIR PROTEIN... 155 9e-37
gi|15835478|ref|NP_297237.1| DNA mismatch repair protein Mu... 153 5e-36
gi|15618721|ref|NP_225007.1| DNA Mismatch Repair [Chlamydop... 151 2e-35
gi|15617225|gb|AAL01156.1| (AY047228) DNA mismatch repair p... 148 2e-34
gi|6324247|ref|NP_014317.1| Required for mismatch repair in... 147 5e-34
gi|172203|gb|AAA34885.1| (M29688) DNA mismatch repair prote... 146 6e-34
gi|6679397|ref|NP_032912.1| postmeiotic segregation increas... 142 2e-32
gi|15639295|ref|NP_218744.1| DNA mismatch repair protein (m... 140 5e-32
gi|8039787|sp|O83325|MUTL_TREPA DNA MISMATCH REPAIR PROTEIN... 140 6e-32
gi|15235373|ref|NP_192155.1| awaiting functional assignment... 139 9e-32
gi|14279172|gb|AAK58517.1|AF252300_2 (AF252300) putative DN... 139 1e-31
gi|7504886|pir||T21957 hypothetical protein H12C20.2a - Cae... 135 1e-30
gi|15806699|ref|NP_295419.1| DNA mismatch repair protein Mu... 132 9e-30
gi|7303075|gb|AAF58142.1| (AE003811) Pms2 gene product [Dro... 129 1e-28
gi|887629|emb|CAA61428.1| (X89016) ORF N2317 [Saccharomyces... 127 4e-28
gi|4505911|ref|NP_000525.1| postmeiotic segregation 1; Post... 125 2e-27
gi|3193224|gb|AAC19245.1| (AF068271) mutL homolog PMS2 [Dro... 121 3e-26
gi|16329972|ref|NP_440700.1| DNA mismatch repair protein; M... 118 2e-25
gi|8928225|sp|P96082|MUTL_THEAQ DNA MISMATCH REPAIR PROTEIN... 107 4e-22
gi|13878584|sp|Q9UHC1|MLH3_HUMAN DNA MISMATCH REPAIR PROTEI... 107 6e-22
gi|14784562|ref|XP_040415.1| mutL (E. coli) homolog 3 [Homo... 107 6e-22
gi|14784569|ref|XP_016395.2| hypothetical protein XP_016395... 107 6e-22
gi|7657337|ref|NP_055196.1| mutL (E. coli) homolog 3; misma... 106 7e-22
gi|1082697|pir||JC2399 PMS4 homolog mismatch repair protein... 105 2e-21
gi|14029392|gb|AAK52671.1| (AF320085) unknown [Magnaporthe ... 103 5e-21
gi|1304125|dbj|BAA07514.1| (D38502) yeast mismatch repair g... 103 5e-21
gi|4699962|gb|AAD28062.1|AC006014_3 (AC006014) similar to m... 102 1e-20
gi|6518488|dbj|BAA87903.1| (AB020210) Mismatch repair enzym... 102 2e-20
gi|6325093|ref|NP_015161.1| Mutl Homolog; Mlh3p [Saccharomy... 101 2e-20
gi|4239950|dbj|BAA74753.1| (AB017004) PMS2L13 [Homo sapiens] 100 4e-20
gi|1304121|dbj|BAA07511.1| (D38499) yeast mismatch repair g... 100 5e-20
gi|1082698|pir||JC2400 PMS5 homolog mismatch repair protein... 100 5e-20
gi|14723301|ref|XP_047605.1| hypothetical protein XP_047605... 100 9e-20
gi|14250028|gb|AAH08410.1|AAH08410 (BC008410) Similar to po... 99 1e-19
gi|4699961|gb|AAD28061.1|AC006014_2 (AC006014) similar to P... 99 1e-19
gi|1082696|pir||JC2398 PMS3 homolog mismatch repair protein... 99 1e-19
gi|4885551|ref|NP_005385.1| postmeiotic segregation increas... 97 5e-19
Alignments
>gi|13878583|sp|Q9JK91|MLH1_MOUSE DNA MISMATCH REPAIR PROTEIN MLH1 (MUTL PROTEIN HOMOLOG 1)
gi|7595954|gb|AAF64514.1|AF250844_1 (AF250844) MutL homolog 1 protein [Mus musculus]
Length = 760
Score = 1292 bits (3344), Expect = 0.0
Identities = 651/760 (85%), Positives = 693/760 (90%), Gaps = 4/760 (0%)
Query: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
M+FVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKST+IQV+VKEGGLKLIQ
Sbjct: 1 MAFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTNIQVVVKEGGLKLIQ 60
Query: 61 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
IQDNGTGIRKEDLDIVCERFTTSKLQ+FEDLASISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61 IQDNGTGIRKEDLDIVCERFTTSKLQTFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
DGKCAYRASYSDGKL+APPKPCAGNQGT ITVEDLFYNI TRRKALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNIITRRKALKNPSEEYGKILEVV 180
Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
GRYS+HN+GISFSVKKQGETV+DVRTLPNA+TVDNIRSIFGNAVSRELIE+GCEDKTLAF
Sbjct: 181 GRYSIHNSGISFSVKKQGETVSDVRTLPNATTVDNIRSIFGNAVSRELIEVGCEDKTLAF 240
Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
KMNGYISNANYSVKKCIFLLFINHRLVES +LRKAIETVYAAYLPKNTHPFLYLSLEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESAALRKAIETVYAAYLPKNTHPFLYLSLEISP 300
Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
QNVDVNVHPTKHEVHFLHEESIL+RVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGE
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILQRVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEAA 360
Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQ--AIVTEDKTD 418
+ DKVYA+QMVRTDSR+QKLDAFLQP+S + SQPQ A V +T+
Sbjct: 361 RPTTGVASSSTSGSGDKVYAYQMVRTDSRDQKLDAFLQPVSSLVPSQPQDPAPVRGARTE 420
Query: 419 ISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSS--NPRKRHRXX 476
S RA ++DEEML LPAPAE AA++++LE ++ TS+ ++K PTSS + RKRHR
Sbjct: 421 GSPERATREDEEMLALPAPAEAAAESENLERESLMETSDAAQKAAPTSSPGSSRKRHRED 480
Query: 477 XXXXXXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNP 536
KEMTAAC PRRRIINLTSVLSLQEEI+E+ HE LRE+L NHSFVGCVNP
Sbjct: 481 SDVEMVENASGKEMTAACYPRRRIINLTSVLSLQEEISERCHETLREILRNHSFVGCVNP 540
Query: 537 QWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESG 596
QWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESG
Sbjct: 541 QWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESG 600
Query: 597 WTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIF 656
WTE+DGPKEGLAEYIVEFLKKKAEMLADYFS+EIDEEGNLIGLPLLID+YVPPLEGLPIF
Sbjct: 601 WTEDDGPKEGLAEYIVEFLKKKAEMLADYFSVEIDEEGNLIGLPLLIDSYVPPLEGLPIF 660
Query: 657 ILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTV 716
ILRLATEVNWDEEKECFESLSKECAMFYSIRKQYI EESTLSGQQS++PGS WKWTV
Sbjct: 661 ILRLATEVNWDEEKECFESLSKECAMFYSIRKQYILEESTLSGQQSDMPGSTSKPWKWTV 720
Query: 717 EHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
EHI+YKA RSH+LPPKHFTEDGN+LQLANLPDLYKVFERC
Sbjct: 721 EHIIYKAFRSHLLPPKHFTEDGNVLQLANLPDLYKVFERC 760
>gi|13591989|ref|NP_112315.1| mismatch repair protein [Rattus norvegicus]
gi|13878571|sp|P97679|MLH1_RAT DNA MISMATCH REPAIR PROTEIN MLH1 (MUTL PROTEIN HOMOLOG 1)
gi|1724118|gb|AAB38506.1| (U80054) mismatch repair protein [Rattus norvegicus]
Length = 757
Score = 1289 bits (3336), Expect = 0.0
Identities = 639/758 (84%), Positives = 684/758 (89%), Gaps = 3/758 (0%)
Query: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEM ENCLDAKST+IQVIV+EGGLKLIQ
Sbjct: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMTENCLDAKSTNIQVIVREGGLKLIQ 60
Query: 61 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
IQDNGTGIRKEDLDIVCERFTTSKLQ+FEDLA ISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61 IQDNGTGIRKEDLDIVCERFTTSKLQTFEDLAMISTYGFRGEALASISHVAHVTITTKTA 120
Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
DGKCAYRASYSDGKL+APPKPCAGNQGT ITVEDLFYNI TR+KALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNIITRKKALKNPSEEYGKILEVV 180
Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
GRYS+HN+GISFSVKKQGETV+DVRTLPNA+TVDNIRSIFGNAVSRELIE+GCEDKTLAF
Sbjct: 181 GRYSIHNSGISFSVKKQGETVSDVRTLPNATTVDNIRSIFGNAVSRELIEVGCEDKTLAF 240
Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
KMNGYISNANYSVKKCIFLLFINHRLVES +L+KAIE VYAAYLPKNTHPFLYL LEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESAALKKAIEAVYAAYLPKNTHPFLYLILEISP 300
Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGE V
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEAV 360
Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
K DKV+A+QMVRTDSR+QKLDAF+QP+S+ L SQPQ V ++T+ S
Sbjct: 361 KSTTGIASSSTSGSGDKVHAYQMVRTDSRDQKLDAFMQPVSRRLPSQPQDPVPGNRTEGS 420
Query: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSE-MSEKRGPTS-SNPRKRHRXXXX 478
+A Q+D+E+ ELPAP E AA + SLE ++ G SE ++ +R P+S + RKRH
Sbjct: 421 PEKAMQKDQEISELPAPMEAAADSASLERESVIGASEVVAPQRHPSSPGSSRKRHPEDSD 480
Query: 479 XXXXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQW 538
RKEMTAAC PRRRIINLTSVLSLQEEIN++GHE LREML NH+FVGCVNPQW
Sbjct: 481 VEMMENDSRKEMTAACYPRRRIINLTSVLSLQEEINDRGHETLREMLRNHTFVGCVNPQW 540
Query: 539 ALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWT 598
ALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRL EPAPLFD AMLALDSPESGWT
Sbjct: 541 ALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLPEPAPLFDFAMLALDSPESGWT 600
Query: 599 EEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFIL 658
EEDGPKEGLAEYIVEFLKKKA+MLADYFS+EIDEEGNLIGLPLLID+YVPPLEGLPIFIL
Sbjct: 601 EEDGPKEGLAEYIVEFLKKKAKMLADYFSVEIDEEGNLIGLPLLIDSYVPPLEGLPIFIL 660
Query: 659 RLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEH 718
RLATEVNWDEE ECFESLSKECA+FYSIRKQYI EES LSGQQS++PGS WKWTVEH
Sbjct: 661 RLATEVNWDEE-ECFESLSKECAVFYSIRKQYILEESALSGQQSDMPGSPSKPWKWTVEH 719
Query: 719 IVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
I+YKA RSH+LPPKHFTEDGN+LQLANLPDL KVFERC
Sbjct: 720 IIYKAFRSHLLPPKHFTEDGNVLQLANLPDLCKVFERC 757
>gi|4557757|ref|NP_000240.1| mutL homolog 1; mutL (E. coli) homolog 1 [Homo sapiens]
gi|14725771|ref|XP_044891.1| mutL homolog 1 [Homo sapiens]
gi|730028|sp|P40692|MLH1_HUMAN DNA MISMATCH REPAIR PROTEIN MLH1 (MUTL PROTEIN HOMOLOG 1)
gi|631299|pir||S43085 DNA mismatch repair protein MLH1 - human
gi|463989|gb|AAC50285.1| (U07343) hMLH1 [Homo sapiens]
gi|1079787|gb|AAA82079.1| (U40978) DNA mismatch repair protein homolog [Homo sapiens]
gi|13905126|gb|AAH06850.1|AAH06850 (BC006850) mutL (E. coli) homolog 1 (colon cancer, nonpolyposis
type 2) [Homo sapiens]
gi|741682|prf||2007430A DNA mismatch repair protein [Homo sapiens]
Length = 756
Score = 1467 bits (3797), Expect = 0.0
Identities = 730/756 (96%), Positives = 730/756 (96%)
Query: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ
Sbjct: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
Query: 61 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF
Sbjct: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
K DKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS
Sbjct: 361 KSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
Query: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXX 480
SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHR
Sbjct: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVE 480
Query: 481 XXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540
RKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL
Sbjct: 481 MVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540
Query: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600
AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE
Sbjct: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600
Query: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660
DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL
Sbjct: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660
Query: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720
ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV
Sbjct: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720
Query: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
Sbjct: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
>gi|466462|gb|AAA17374.1| (U07418) human homolog of E. coli mutL gene product, Swiss-Prot
Accession Number P23367 [Homo sapiens]
Length = 756
Score = 1466 bits (3796), Expect = 0.0
Identities = 729/756 (96%), Positives = 730/756 (96%)
Query: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ
Sbjct: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
Query: 61 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRS+FGNAVSRELIEIGCEDKTLAF
Sbjct: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSVFGNAVSRELIEIGCEDKTLAF 240
Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
K DKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS
Sbjct: 361 KSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
Query: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXX 480
SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHR
Sbjct: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVE 480
Query: 481 XXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540
RKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL
Sbjct: 481 MVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540
Query: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600
AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE
Sbjct: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600
Query: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660
DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL
Sbjct: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660
Query: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720
ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV
Sbjct: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720
Query: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
Sbjct: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
>gi|604369|gb|AAA85687.1| (U17857) hMLH1 gene product [Homo sapiens]
Length = 752
Score = 1453 bits (3761), Expect = 0.0
Identities = 726/756 (96%), Positives = 726/756 (96%), Gaps = 4/756 (0%)
Query: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ
Sbjct: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
Query: 61 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV
Sbjct: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVV 180
Query: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF
Sbjct: 181 GRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF 240
Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP
Sbjct: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV
Sbjct: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMV 360
Query: 361 KXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
K DKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS
Sbjct: 361 KSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDIS 420
Query: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXX 480
SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHR
Sbjct: 421 SGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVE 480
Query: 481 XXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540
RKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL
Sbjct: 481 MVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWAL 540
Query: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600
AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE
Sbjct: 541 AQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEE 600
Query: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660
DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL
Sbjct: 601 DGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRL 660
Query: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIV 720
ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPG SWKWTVEHIV
Sbjct: 661 ATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPG----SWKWTVEHIV 716
Query: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
Sbjct: 717 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 752
>gi|12835158|dbj|BAB23172.1| (AK004105) putative [Mus musculus]
Length = 484
Score = 753 bits (1944), Expect = 0.0
Identities = 390/484 (80%), Positives = 418/484 (85%), Gaps = 4/484 (0%)
Query: 277 ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLG 336
ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESIL+RVQQHIESKLLG
Sbjct: 1 ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILQRVQQHIESKLLG 60
Query: 337 SNSSRMYFTQTLLPGLAGPSGEMVKXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAF 396
SNSSRMYFTQTLLPGLAGPSGE + DKVYA+QMVRTDSREQKLDAF
Sbjct: 61 SNSSRMYFTQTLLPGLAGPSGEAARPTTGVASSSTSGSGDKVYAYQMVRTDSREQKLDAF 120
Query: 397 LQPLSKPLSSQPQ--AIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKG 454
LQP+S SQPQ A V +T+ S RA ++DEEML LPAPAE AA++++LE ++
Sbjct: 121 LQPVSSLGPSQPQDPAPVRGARTEGSPERATREDEEMLALPAPAEAAAESENLERESLME 180
Query: 455 TSEMSEKRGPTSS--NPRKRHRXXXXXXXXXXXXRKEMTAACTPRRRIINLTSVLSLQEE 512
TS+ ++K PTSS + RKRHR KEMTAAC PRRRIINLTSVLSLQEE
Sbjct: 181 TSDAAQKAAPTSSPGSSRKRHREDSDVEMVENASGKEMTAACYPRRRIINLTSVLSLQEE 240
Query: 513 INEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFG 572
I+E+ HE LREML NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFG
Sbjct: 241 ISERCHETLREMLRNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFG 300
Query: 573 VLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDE 632
VLRLSEPAPLFD AMLALDSPESGWTE+DGPKEGLAEYIVEFLKKKAEMLADYFS+EIDE
Sbjct: 301 VLRLSEPAPLFDRAMLALDSPESGWTEDDGPKEGLAEYIVEFLKKKAEMLADYFSVEIDE 360
Query: 633 EGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYIS 692
EGNLIGLPLLID+YVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYI
Sbjct: 361 EGNLIGLPLLIDSYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYIL 420
Query: 693 EESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKV 752
EESTLSGQQS++PGS WKWTVEHI+YKA RSH+LPPKHFTEDGN+LQLANLPDLYKV
Sbjct: 421 EESTLSGQQSDMPGSTSKPWKWTVEHIIYKAFRSHLLPPKHFTEDGNVLQLANLPDLYKV 480
Query: 753 FERC 756
FERC
Sbjct: 481 FERC 484
>gi|13543339|gb|AAH05833.1|AAH05833 (BC005833) Similar to mutL (E. coli) homolog 1 (colon cancer,
nonpolyposis type 2) [Homo sapiens]
gi|13543417|gb|AAH05866.1|AAH05866 (BC005866) Similar to mutL (E. coli) homolog 1 (colon cancer,
nonpolyposis type 2) [Homo sapiens]
Length = 374
Score = 731 bits (1886), Expect = 0.0
Identities = 362/374 (96%), Positives = 362/374 (96%)
Query: 383 MVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAA 442
MVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAA
Sbjct: 1 MVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAA 60
Query: 443 KNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXXXXXXXXRKEMTAACTPRRRIIN 502
KNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHR RKEMTAACTPRRRIIN
Sbjct: 61 KNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIIN 120
Query: 503 LTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQ 562
LTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQ
Sbjct: 121 LTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQ 180
Query: 563 ILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEML 622
ILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEML
Sbjct: 181 ILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEML 240
Query: 623 ADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM 682
ADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM
Sbjct: 241 ADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM 300
Query: 683 FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQ 742
FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQ
Sbjct: 301 FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQ 360
Query: 743 LANLPDLYKVFERC 756
LANLPDLYKVFERC
Sbjct: 361 LANLPDLYKVFERC 374
>gi|7304079|gb|AAF59117.1| (AE003838) Mlh1 gene product [Drosophila melanogaster]
Length = 664
Score = 615 bits (1586), Expect = e-175
Identities = 335/751 (44%), Positives = 453/751 (59%), Gaps = 94/751 (12%)
Query: 6 GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNG 65
GVIR+LDE VVNRIAAGE+IQRPANA+KE++EN LDA+ST IQV VK GGLKL+QIQDNG
Sbjct: 8 GVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNG 67
Query: 66 TGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCA 125
TGIR+EDL IVCERFTTSKL FEDL+ I+T+GFRGEALASISHVAH++I TKTA KC
Sbjct: 68 TGIRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCG 127
Query: 126 YRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSV 185
Y+A+Y+DGKL+ PKPCAGNQGT I +EDLFYN+ RR+AL++P+EE+ ++ EV+ RY+V
Sbjct: 128 YKATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRRQALRSPAEEFQRLSEVLARYAV 187
Query: 186 HNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
HN + F+++KQG+ +RT +S +NIR I+G A+S+EL+E D+ F+
Sbjct: 188 HNPRVGFTLRKQGDAQPALRTPVASSRSENIRIIYGAAISKELLEFSHRDEVYKFEAECL 247
Query: 246 ISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDV 305
I+ NYS KKC LLFIN RLVEST+LR +++++YA YLP+ HPF+Y+SL + PQN+DV
Sbjct: 248 ITQVNYSAKKCQMLLFINQRLVESTALRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDV 307
Query: 306 NVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKXXXX 365
NVHPTKHEVHFL++E I++ ++Q +E++LLGSN++R ++ Q LPG P + +
Sbjct: 308 NVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTFYKQLRLPG--APDLDETQ---- 361
Query: 366 XXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRAR 425
++Y +MVRTDS EQKLD FL PL K S + E A
Sbjct: 362 -----LADKTQRIYPKEMVRTDSTEQKLDKFLAPLVKSDSGVSSSSSQE---------AS 407
Query: 426 QQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXXXXXXX 485
+ EE + A K+ R
Sbjct: 408 RLPEESFRVTAA---------------------------------KKSREVRLSSVLDMR 434
Query: 486 XRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQT 545
R E + R + NL V + E HE M + SF
Sbjct: 435 KRVERQCSVQLRSTLKNLVYVGCVDERRALFQHETRLYMCNTRSF--------------- 479
Query: 546 KLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKE 605
SEELFYQ +IY+F N + +S P PL +L +L+L+S +GWT EDG K
Sbjct: 480 ----------SEELFYQRMIYEFQNCSEITISPPLPLKELLILSLESEAAGWTPEDGDKA 529
Query: 606 GLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVN 665
LA+ + L KKA ++ +YF L I E+G L LP L+ + P + LP+++LRLATEV+
Sbjct: 530 ELADGAADILLKKAPIMREYFGLRISEDGMLESLPSLLHQHRPCVAHLPVYLLRLATEVD 589
Query: 666 WDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALR 725
W++E CFE+ +E A FY+ Q G+ +WT+EH+++ A +
Sbjct: 590 WEQETRCFETFCRETARFYA--------------QLDWREGATAGFSRWTMEHVLFPAFK 635
Query: 726 SHILPPKHFTEDGNILQLANLPDLYKVFERC 756
++LPP + I +L NLP LYKVFERC
Sbjct: 636 KYLLPPPRIKD--QIYELTNLPTLYKVFERC 664
>gi|3192877|gb|AAC19117.1| (AF068257) mutL homolog [Drosophila melanogaster]
Length = 663
Score = 608 bits (1568), Expect = e-173
Identities = 334/751 (44%), Positives = 453/751 (59%), Gaps = 95/751 (12%)
Query: 6 GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNG 65
GVIR+LDE VVNRIAAGE+IQRPANA+KE++EN LDA+ST IQV VK GGLKL+QIQDNG
Sbjct: 8 GVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNG 67
Query: 66 TGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCA 125
TGIR+EDL IVCERFTTSKL FEDL+ I+T+GFRGEALASISHVAH++I TKTA KC
Sbjct: 68 TGIRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCG 127
Query: 126 YRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSV 185
Y+A+Y+DGKL+ PKPCAGNQGT I +EDLFYN+ RR+AL++P+EE+ ++ EV+ RY+V
Sbjct: 128 YKATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRRQALRSPAEEFQRLSEVLARYAV 187
Query: 186 HNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
HN + F+++KQG+ +RT +S +NIR I+G A+S+EL+E D+ F+
Sbjct: 188 HNPRVGFTLRKQGDAQPALRTPVASSRSENIRIIYGAAISKELLEFSHRDEVYKFEAECL 247
Query: 246 ISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDV 305
I+ NYS KKC LLFIN RLVEST+LR +++++YA YLP+ HPF+Y+SL + PQN+DV
Sbjct: 248 ITQVNYSAKKCQMLLFINQRLVESTALRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDV 307
Query: 306 NVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKXXXX 365
NVHPTKHEVHFL++E I++ ++Q +E++LLGSN++R ++ Q LPG P + +
Sbjct: 308 NVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTFYKQLRLPG--APDLDETQ---- 361
Query: 366 XXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRAR 425
++Y +MVRTDS EQKLD FL PL K S + E A
Sbjct: 362 -----LADKTQRIYPKEMVRTDSTEQKLDKFLAPLVKSDSGVSSSSSQE---------AS 407
Query: 426 QQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXXXXXXXXXXX 485
+ EE + A K+ R
Sbjct: 408 RLPEESFRVTAA---------------------------------KKSREVRLSSVLDMR 434
Query: 486 XRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQT 545
R E + R + NL V + E HE M + SF
Sbjct: 435 KRVERQCSVQLRSTLKNLVYVGCVDERRALFQHETRLYMCNTRSF--------------- 479
Query: 546 KLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKE 605
SEELFYQ +IY+F N + + P PL +L +L+L+S +GWT ED K
Sbjct: 480 ----------SEELFYQRMIYEFQNCSEITICPPLPLKELLILSLESRAAGWTPEDEDKA 529
Query: 606 GLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVN 665
LA+ + L KKA ++ +YF L I E+G L LP L+ + P + LP+++LRLATEV+
Sbjct: 530 ELADGAADILLKKAPIMREYFGLRISEDGMLESLPSLLHQHRPCVAHLPVYLLRLATEVD 589
Query: 666 WDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALR 725
W++E CFE+ +E A FY+ Q G+ +WT+EH+++ A +
Sbjct: 590 WEQETRCFETFCRETARFYA--------------QLDWREGATAVFSRWTMEHVLFPAFK 635
Query: 726 SHILPPKHFTEDGNILQLANLPDLYKVFERC 756
++LPP+ +D I +L NLP LYKVFERC
Sbjct: 636 KYLLPPR--IKD-QIYELTNLPTLYKVFERC 663
>gi|460627|gb|AAA16835.1| (U07187) Mlh1p [Saccharomyces cerevisiae]
Length = 769
Score = 471 bits (1213), Expect = e-132
Identities = 292/788 (37%), Positives = 448/788 (56%), Gaps = 62/788 (7%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ LD +VVN+IAAGE+I P NA+KEM+EN +DA +T I ++VKEGG+K++QI DNG+G
Sbjct: 5 IKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSG 64
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I K DL I+CERFTTSKLQ FEDL+ I TYGFRGEALASISHVA VT+TTK + +CA+R
Sbjct: 65 INKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWR 124
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
SY++GK+ PKP AG GT I VEDLF+NI +R +AL++ ++EY KIL+VVGRY++H+
Sbjct: 125 VSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRLRALRSHNDEYSKILDVVGRYAIHS 184
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEI---GCEDKTLAFKMNG 244
I FS KK G++ + P+ + D IR++F +V+ LI ED L ++G
Sbjct: 185 KDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFNKSVASNLITFHISKVEDLNLE-SVDG 243
Query: 245 YISNANYSVKKCIFLL-FINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+ N N+ KK I L+ FIN+RLV LR+A+ +VY+ YLPK PF+YL + I P V
Sbjct: 244 KVCNLNFISKKSISLIFFINNRLVTCDLLRRALNSVYSNYLPKGFRPFIYLGIVIDPAAV 303
Query: 304 DVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTL---LPGLAGPSGEMV 360
DVNVHPTK EV FL ++ I+E++ + ++L ++SR + ++ P P + +
Sbjct: 304 DVNVHPTKREVRFLSQDEIIEKIANQLHAELSAIDTSRTFKASSISTNKPESLIPFNDTI 363
Query: 361 KXXXXXXXXXXXXXXDKVYA-------------HQMVRTDSREQKLDAFL---QPLSKPL 404
+ + Y +++VR D+ + K+ +FL Q +
Sbjct: 364 ESDRNRKSLRQAQVVENSYTTANSQLRKAKRQENKLVRIDASQAKITSFLSSSQQFNFEG 423
Query: 405 SSQPQAIVTEDKTDISSGRARQQDEEMLEL---PAPAEVAAKNQSLEGDTTKGTSEMSEK 461
SS + + T++S Q+ E L L P + N + D K ++ +
Sbjct: 424 SSTKRQLSEPKVTNVS----HSQEAEKLTLNESEQPRDANTINDNDLKDQPKKKQKLGDY 479
Query: 462 RGPTSSNPRKRHRXXXXXXXXXXXXRKEMTAACTPRRRI-INLTSVLSLQEEINEQGHEV 520
+ P+ ++ K P+ R+ +NLTS+ L+E++++ H
Sbjct: 480 KVPSIADDEKNALPISKDGYIR-----------VPKERVNVNLTSIKKLREKVDDSIHRE 528
Query: 521 LREMLHNHSFVGCVNPQWALA--QHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSE 578
L ++ N ++VG V+ + LA QH KL+L++ + ELFYQI + DFANFG + L
Sbjct: 529 LTDIFANLNYVGVVDEERRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDFANFGKINLQS 588
Query: 579 PAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEG---- 634
D+ + L S E +D KE + I + + ML +Y+S+E+ +G
Sbjct: 589 TNVSDDIVLYNLLS-EFDELNDDASKEKIISKIWDM----SSMLNEYYSIELVNDGLDND 643
Query: 635 ----NLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFY--SIRK 688
L LPLL+ Y+P L LP FI RL EV+W++E+EC + + +E A+ Y +
Sbjct: 644 LKSVKLKSLPLLLKGYIPSLVKLPFFIYRLGKEVDWEDEQECLDGILREIALLYIPDMVP 703
Query: 689 QYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPD 748
+ + +++LS + + +EH+++ ++ L P+H +D ++++ANLPD
Sbjct: 704 KVDTLDASLSEDEKAQFINRKEHISSLLEHVLFPCIKRRFLAPRHILKD--VVEIANLPD 761
Query: 749 LYKVFERC 756
LYKVFERC
Sbjct: 762 LYKVFERC 769
>gi|6323819|ref|NP_013890.1| Required for mismatch repair in mitosis and meiosis, low levels of
postmeiotic segregation, and high spore viability; Mlh1p
[Saccharomyces cerevisiae]
gi|1709056|sp|P38920|MLH1_YEAST MUTL PROTEIN HOMOLOG 1 (DNA MISMATCH REPAIR PROTEIN MLH1)
gi|1078120|pir||S54525 mismatch repair protein MLH1 - yeast (Saccharomyces cerevisiae)
gi|825572|emb|CAA89803.1| (Z49705) Mlh1p [Saccharomyces cerevisiae]
Length = 769
Score = 471 bits (1212), Expect = e-131
Identities = 291/788 (36%), Positives = 447/788 (55%), Gaps = 62/788 (7%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ LD +VVN+IAAGE+I P NA+KEM+EN +DA +T I ++VKEGG+K++QI DNG+G
Sbjct: 5 IKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSG 64
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I K DL I+CERFTTSKLQ FEDL+ I TYGFRGEALASISHVA VT+TTK + +CA+R
Sbjct: 65 INKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWR 124
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
SY++GK+ PKP AG GT I VEDLF+NI +R +AL++ ++EY KIL+VVGRY++H+
Sbjct: 125 VSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRLRALRSHNDEYSKILDVVGRYAIHS 184
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEI---GCEDKTLAFKMNG 244
I FS KK G++ + P+ + D IR++F +V+ LI ED L ++G
Sbjct: 185 KDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFNKSVASNLITFHISKVEDLNLE-SVDG 243
Query: 245 YISNANYSVKKCIF-LLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+ N N+ KK I + FIN+RLV LR+A+ +VY+ YLPK PF+YL + I P V
Sbjct: 244 KVCNLNFISKKSISPIFFINNRLVTCDLLRRALNSVYSNYLPKGNRPFIYLGIVIDPAAV 303
Query: 304 DVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTL---LPGLAGPSGEMV 360
DVNVHPTK EV FL ++ I+E++ + ++L ++SR + ++ P P + +
Sbjct: 304 DVNVHPTKREVRFLSQDEIIEKIANQLHAELSAIDTSRTFKASSISTNKPESLIPFNDTI 363
Query: 361 KXXXXXXXXXXXXXXDKVYA-------------HQMVRTDSREQKLDAFL---QPLSKPL 404
+ + Y +++VR D+ + K+ +FL Q +
Sbjct: 364 ESDRNRKSLRQAQVVENSYTTANSQLRKAKRQENKLVRIDASQAKITSFLSSSQQFNFEG 423
Query: 405 SSQPQAIVTEDKTDISSGRARQQDEEMLEL---PAPAEVAAKNQSLEGDTTKGTSEMSEK 461
SS + + T++S Q+ E L L P + N + D K ++ +
Sbjct: 424 SSTKRQLSEPKVTNVS----HSQEAEKLTLNESEQPRDANTINDNDLKDQPKKKQKLGDY 479
Query: 462 RGPTSSNPRKRHRXXXXXXXXXXXXRKEMTAACTPRRRI-INLTSVLSLQEEINEQGHEV 520
+ P+ ++ K P+ R+ +NLTS+ L+E++++ H
Sbjct: 480 KVPSIADDEKNALPISKDGYIR-----------VPKERVNVNLTSIKKLREKVDDSIHRE 528
Query: 521 LREMLHNHSFVGCVNPQWALA--QHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSE 578
L ++ N ++VG V+ + LA QH KL+L++ + ELFYQI + DFANFG + L
Sbjct: 529 LTDIFANLNYVGVVDEERRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDFANFGKINLQS 588
Query: 579 PAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEG---- 634
D+ + L S E +D KE + I + + ML +Y+S+E+ +G
Sbjct: 589 TNVSDDIVLYNLLS-EFDELNDDASKEKIISKIWDM----SSMLNEYYSIELVNDGLDND 643
Query: 635 ----NLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFY--SIRK 688
L LPLL+ Y+P L LP FI RL EV+W++E+EC + + +E A+ Y +
Sbjct: 644 LKSVKLKSLPLLLKGYIPSLVKLPFFIYRLGKEVDWEDEQECLDGILREIALLYIPDMVP 703
Query: 689 QYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPD 748
+ + +++LS + + +EH+++ ++ L P+H +D ++++ANLPD
Sbjct: 704 KVDTSDASLSEDEKAQFINRKEHISSLLEHVLFPCIKRRFLAPRHILKD--VVEIANLPD 761
Query: 749 LYKVFERC 756
LYKVFERC
Sbjct: 762 LYKVFERC 769
>gi|11280245|pir||T50317 probable DNA mismatch repair protein, MLH1 homolog [imported] -
fission yeast (Schizosaccharomyces pombe)
gi|6723918|emb|CAB66448.1| (AL136536) putative DNA mismatch repair protein, MLH1 homolog
[Schizosaccharomyces pombe]
Length = 684
Score = 415 bits (1067), Expect = e-115
Identities = 277/763 (36%), Positives = 407/763 (53%), Gaps = 101/763 (13%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
IR LD+ V+N+IAAGE+I+RP NAIKE+IEN LDA STSI V++K+GGLKL+QI DNG+G
Sbjct: 9 IRPLDQLVINKIAAGEIIERPENAIKELIENSLDAGSTSIDVLLKDGGLKLLQITDNGSG 68
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I+ +DL +C+RF+TSK+ +F DL + T+GFRGEALASISHVA VT+ TK + A++
Sbjct: 69 IQYDDLPYLCQRFSTSKIDNFNDLQHLQTFGFRGEALASISHVAKVTVVTKLSSDIHAWK 128
Query: 128 ASYSDGKLKAP--------PKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEV 179
A Y DG L AP P+PCAG QGT IT EDLFYN+ +R+ ALKN SEE+ +I+ +
Sbjct: 129 AFYVDGAL-APISPGMSPAPQPCAGKQGTVITAEDLFYNVRSRKSALKNGSEEFRRIMIL 187
Query: 180 VGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGC---EDK 236
V +Y++HN +SF+ KK G+TVA + S D IR I+G V+ L + +
Sbjct: 188 VQKYAIHNDQVSFNCKKVGDTVASLSLSSRLSKADKIRHIYGPRVASHLRDFSLGEGQSS 247
Query: 237 TLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSL 296
+ F NG+ISNA++ KK +LFIN+RLVES LR A+E YA YL K F+YLSL
Sbjct: 248 IVGFSANGFISNADFQDKKSNLILFINNRLVESVELRHALEETYAKYLHKGASYFVYLSL 307
Query: 297 EISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPS 356
+SP+ +DVNVHP+K VHFL+++ I + + L +++ R Y Q ++P ++
Sbjct: 308 NMSPEQLDVNVHPSKRIVHFLYDQEIATSICDKLGEILERTDTERSYPLQAMIPSISNTK 367
Query: 357 GEMVKXXXXXXXXXXXXXXDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDK 416
+ Y + +VRTD RE+ + + L
Sbjct: 368 NAESSSQKAV----------RTYENYLVRTDPRERSIKSMLS------------------ 399
Query: 417 TDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHRXX 476
+ + D E++E + A N++ D +E + G +
Sbjct: 400 DNFLQRSSNNYDNEIIE---KVDSANSNKNATNDIKDLQTEEIVEEGNSI---------- 446
Query: 477 XXXXXXXXXXRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNP 536
++ + + ++++IN VL+ +L H +VG V P
Sbjct: 447 ------------DLESIKSLQKQVINSMHVLATN-------------ILTEHKYVGLVCP 481
Query: 537 --QWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPE 594
+ A QH LY+++ KLS LFYQI + +F N+G L P + DL +
Sbjct: 482 TRRIAAVQHNIGLYVVDYGKLSYHLFYQICLTEFGNYGEFVLETPLSISDLFEIV----- 536
Query: 595 SGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLP 654
+G +ED + +E L + +ML DYFS+ + G L +P+L Y PP E LP
Sbjct: 537 NG--DEDKSE---SEKFTRLLVSRRDMLKDYFSISVTSGGLLTAVPMLSPKYHPPFEQLP 591
Query: 655 IFILRLATE-VNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWK 713
+ I L + +W +EK C + K A FY LS ++S+V SI S +
Sbjct: 592 LLISSLTPKFFDWLDEKSCLNGIMKAIAKFYV--------PLPLSYEESDVK-SI-RSLE 641
Query: 714 WTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
+E ++ R ++ PK E+ I Q+ +LP LY VFERC
Sbjct: 642 SCLEDYLFPEFRRRVICPKKVFEEKCIYQITSLPRLYNVFERC 684
>gi|13430732|gb|AAK25988.1|AF360278_1 (AF360278) putative MLH1 protein [Arabidopsis thaliana]
Length = 727
Score = 384 bits (986), Expect = e-105
Identities = 201/418 (48%), Positives = 286/418 (68%), Gaps = 33/418 (7%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+RL+E+VVNRIAAGEVIQRP +A+KE++EN LDA S+SI V+VK+GGLKLIQ+ D+G G
Sbjct: 19 IQRLEESVVNRIAAGEVIQRPVSAVKELVENSLDADSSSISVVVKDGGLKLIQVSDDGHG 78
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
IR+EDL I+CER TTSKL FEDL S+S+ GFRGEALAS+++VAHVT+TT T YR
Sbjct: 79 IRREDLPILCERHTTSKLTKFEDLFSLSSMGFRGEALASMTYVAHVTVTTITKGQIHGYR 138
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
SY DG ++ PK CA +GTQI VE+LFYN+ RRK L+N +++YGKI++++ R ++H
Sbjct: 139 VSYRDGVMEHEPKACAAVKGTQIMVENLFYNMIARRKTLQNSADDYGKIVDLLSRMAIHY 198
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEI---GCEDKTLAFKMNG 244
+SFS +K G ADV ++ + S +D+IRS++G +V++ L+++ C+ F M G
Sbjct: 199 NNVSFSCRKHGAVKADVHSVVSPSRLDSIRSVYGVSVAKNLMKVEVSSCDSSGCTFDMEG 258
Query: 245 YISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVD 304
+ISN+NY KK I +LFIN RLVE ++L++AIE VYAA LPK + PF+Y+S+ + ++VD
Sbjct: 259 FISNSNYVAKKTILVLFINDRLVECSALKRAIEIVYAATLPKASKPFVYMSINLPREHVD 318
Query: 305 VNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMY------FTQTLL-------PG 351
+N+HPTK EV L++E I+E +Q +E KL +N +R + + Q+ L P
Sbjct: 319 INIHPTKKEVSLLNQEIIIEMIQSEVEVKLRNANDTRTFQEQKVEYIQSTLTSQKSDSPV 378
Query: 352 LAGPSGEMVKXXXXXXXXXXXXXXDKVYAHQMVRTDSREQ--KLDAFLQPLSKPLSSQ 407
PSG+ + KV ++MVRTDS + +L AFLQP + L +
Sbjct: 379 SQKPSGQKTQ---------------KVPVNKMVRTDSSDPAGRLHAFLQPKPQSLPDK 421
Score = 176 bits (447), Expect = 6e-43
Identities = 97/285 (34%), Positives = 162/285 (56%), Gaps = 30/285 (10%)
Query: 502 NLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFY 561
+L+SV L ++ H + E + N ++VG + +AL Q+ T LYL N LS+EL Y
Sbjct: 443 DLSSVQELIAGVDSCCHPGMLETVRNCTYVGMADDVFALVQYNTHLYLANVVNLSKELMY 502
Query: 562 QILIYDFANFGVLRLSEPAPLFDLAMLAL--DSPESGWTEEDGPKEGLAEYIVEFLKKKA 619
Q + FA+F ++LS+PAPL +L +LAL + + G +D KE +AE E LK+KA
Sbjct: 503 QQTLRRFAHFNAIQLSDPAPLSELILLALKEEDLDPGNDTKDDLKERIAEMNTELLKEKA 562
Query: 620 EMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKE 679
EML +YFS+ ID NL LP+++D Y P ++ +P F+L L +V W++EK CF+ +S
Sbjct: 563 EMLEEYFSVHIDSSANLSRLPVILDQYTPDMDRVPEFLLCLGNDVEWEDEKSCFQGVSAA 622
Query: 680 CAMFYSIRK-----------QYISEESTLSGQQSEVPGSI--------------PNSW-- 712
FY++ Q+ S+ S ++S++ G++ N+W
Sbjct: 623 IGNFYAMHPPLLPNPSGDGIQFYSKRGESSQEKSDLEGNVDMEDNLDQDLLSDAENAWAQ 682
Query: 713 -KWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
+W+++H+++ ++R + PP +G +++A+L LYK+FERC
Sbjct: 683 REWSIQHVLFPSMRLFLKPPASMASNGTFVKVASLEKLYKIFERC 727
>gi|15233750|ref|NP_192653.1| MLH1 protein [Arabidopsis thaliana]
gi|11357265|pir||T51620 DNA mismatch repair protein MLH1 [imported] - Arabidopsis thaliana
(fragment)
gi|3893081|emb|CAA10163.1| (AJ012747) MLH1 protein [Arabidopsis thaliana]
gi|7267557|emb|CAB78038.1| (AL161514) MLH1 protein [Arabidopsis thaliana]
Length = 737
Score = 384 bits (986), Expect = e-105
Identities = 201/418 (48%), Positives = 286/418 (68%), Gaps = 33/418 (7%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+RL+E+VVNRIAAGEVIQRP +A+KE++EN LDA S+SI V+VK+GGLKLIQ+ D+G G
Sbjct: 29 IQRLEESVVNRIAAGEVIQRPVSAVKELVENSLDADSSSISVVVKDGGLKLIQVSDDGHG 88
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
IR+EDL I+CER TTSKL FEDL S+S+ GFRGEALAS+++VAHVT+TT T YR
Sbjct: 89 IRREDLPILCERHTTSKLTKFEDLFSLSSMGFRGEALASMTYVAHVTVTTITKGQIHGYR 148
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
SY DG ++ PK CA +GTQI VE+LFYN+ RRK L+N +++YGKI++++ R ++H
Sbjct: 149 VSYRDGVMEHEPKACAAVKGTQIMVENLFYNMIARRKTLQNSADDYGKIVDLLSRMAIHY 208
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEI---GCEDKTLAFKMNG 244
+SFS +K G ADV ++ + S +D+IRS++G +V++ L+++ C+ F M G
Sbjct: 209 NNVSFSCRKHGAVKADVHSVVSPSRLDSIRSVYGVSVAKNLMKVEVSSCDSSGCTFDMEG 268
Query: 245 YISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVD 304
+ISN+NY KK I +LFIN RLVE ++L++AIE VYAA LPK + PF+Y+S+ + ++VD
Sbjct: 269 FISNSNYVAKKTILVLFINDRLVECSALKRAIEIVYAATLPKASKPFVYMSINLPREHVD 328
Query: 305 VNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMY------FTQTLL-------PG 351
+N+HPTK EV L++E I+E +Q +E KL +N +R + + Q+ L P
Sbjct: 329 INIHPTKKEVSLLNQEIIIEMIQSEVEVKLRNANDTRTFQEQKVEYIQSTLTSQKSDSPV 388
Query: 352 LAGPSGEMVKXXXXXXXXXXXXXXDKVYAHQMVRTDSREQ--KLDAFLQPLSKPLSSQ 407
PSG+ + KV ++MVRTDS + +L AFLQP + L +
Sbjct: 389 SQKPSGQKTQ---------------KVPVNKMVRTDSSDPAGRLHAFLQPKPQSLPDK 431
Score = 176 bits (447), Expect = 6e-43
Identities = 97/285 (34%), Positives = 162/285 (56%), Gaps = 30/285 (10%)
Query: 502 NLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFY 561
+L+SV L ++ H + E + N ++VG + +AL Q+ T LYL N LS+EL Y
Sbjct: 453 DLSSVQELIAGVDSCCHPGMLETVRNCTYVGMADDVFALVQYNTHLYLANVVNLSKELMY 512
Query: 562 QILIYDFANFGVLRLSEPAPLFDLAMLAL--DSPESGWTEEDGPKEGLAEYIVEFLKKKA 619
Q + FA+F ++LS+PAPL +L +LAL + + G +D KE +AE E LK+KA
Sbjct: 513 QQTLRRFAHFNAIQLSDPAPLSELILLALKEEDLDPGNDTKDDLKERIAEMNTELLKEKA 572
Query: 620 EMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKE 679
EML +YFS+ ID NL LP+++D Y P ++ +P F+L L +V W++EK CF+ +S
Sbjct: 573 EMLEEYFSVHIDSSANLSRLPVILDQYTPDMDRVPEFLLCLGNDVEWEDEKSCFQGVSAA 632
Query: 680 CAMFYSIRK-----------QYISEESTLSGQQSEVPGSI--------------PNSW-- 712
FY++ Q+ S+ S ++S++ G++ N+W
Sbjct: 633 IGNFYAMHPPLLPNPSGDGIQFYSKRGESSQEKSDLEGNVDMEDNLDQDLLSDAENAWAQ 692
Query: 713 -KWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
+W+++H+++ ++R + PP +G +++A+L LYK+FERC
Sbjct: 693 REWSIQHVLFPSMRLFLKPPASMASNGTFVKVASLEKLYKIFERC 737
>gi|7508639|pir||T25389 hypothetical protein T28A8.7 - Caenorhabditis elegans
gi|3880333|emb|CAB07283.1| (Z92813) predicted using Genefinder~contains similarity to Pfam
domain: PF01119 (DNA mismatch repair protein),
Score=389.6, E-value=9.7e-114, N=1~cDNA EST yk6a2.3
comes from this gene~cDNA EST yk6a2.5 comes from this
gene~cDNA EST yk46g7.5 comes from t>
Length = 779
Score = 375 bits (963), Expect = e-103
Identities = 260/792 (32%), Positives = 398/792 (49%), Gaps = 78/792 (9%)
Query: 6 GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNG 65
G+I+RL + VVNR+AAGEV+ RP NAIKE++EN LDA +T I V ++ GGLKL+Q+ DNG
Sbjct: 23 GLIQRLPQDVVNRMAAGEVLARPCNAIKELVENSLDAGATEIMVNMQNGGLKLLQVSDNG 82
Query: 66 TGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCA 125
GI +ED +VCERF TSKLQ FEDL + TYGFRGEALAS+SHVA V I +K AD KCA
Sbjct: 83 KGIEREDFALVCERFATSKLQKFEDLMHMKTYGFRGEALASLSHVAKVNIVSKRADAKCA 142
Query: 126 YRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSV 185
Y+A++ DGK+ A KP AG GT IT DLFYN+ TRR + EE + + + R+++
Sbjct: 143 YQANFLDGKMTADTKPAAGKNGTCITATDLFYNLPTRRNKMTTHGEEAKMVNDTLLRFAI 202
Query: 186 HNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
H +SF++++ D RT + + D + ++ G V+ ++ + L F G+
Sbjct: 203 HRPDVSFALRQN--QAGDFRTKGDGNFRDVVCNLLGRDVADTILPLSLNSTRLKFTFTGH 260
Query: 246 ISN----------ANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHP-FLYL 294
IS N + F +FIN R V L+ I+ V A + H F L
Sbjct: 261 ISKPIASATAAIAQNRKTSRSFFSVFINGRSVRCDILKHPIDEVLGA---RQLHAQFCAL 317
Query: 295 SLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIES---KLLGSNSSRMYFTQTLLPG 351
L+I +DVNVHPTK+ V FL +E I+E ++ + E ++ G + + + P
Sbjct: 318 HLQIDETRIDVNVHPTKNSVIFLEKEEIIEEIRAYFEKVIGEIFGFEALDVEKPEEEQPD 377
Query: 352 LAG----PSGEMVK---------XXXXXXXXXXXXXXDKVYAHQM-VRTDSREQKLDAFL 397
+ P + +K DK M VRTD++E+K+D F
Sbjct: 378 IENLVMIPMSQSLKSIEAIRKPDTKPEFKSSPSAWKSDKKRVDYMEVRTDAKERKIDEF- 436
Query: 398 QPLSKPLSSQPQAIVTEDKTDISSG-----RARQQDEEMLELPAPAEVAAKNQSLEGDTT 452
+++ + P T DI G RAR +D E ++ + + D
Sbjct: 437 --VTRGGAVGP----TTSNDDIFGGSGILKRARTEDS------TGGEKEPEDLNTDFDDV 484
Query: 453 KGTSEMSEKRGPTSSNPRKRHRXXXXXXXXXXXXRKEMTAACTPRRRIINLTSVLSLQEE 512
S +S G R+ + T R + S+ L++E
Sbjct: 485 SMVSLVSTADG------RRLNESQDLGEDDDVDFEYGKT------HREFHFESIEVLRKE 532
Query: 513 INEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFG 572
I + LREM +FVG +N + L Q T LY L+ + + E FYQI ++ F N+G
Sbjct: 533 IIANSSQSLREMFKTSTFVGSINVKQVLIQFGTSLYHLDFSTVLREFFYQISVFSFGNYG 592
Query: 573 VLRLSE--PAPLFDLAMLA-LDSPESGWTEEDGPKEGLAEYIVE-FLKKKAEMLADYFSL 628
RL E PA + L +L L + E + + + E L + A++L DYF++
Sbjct: 593 SYRLDEEPPAIIEILELLGELSTREPNYAAFEVFANVENRFAAEKLLAEHADLLHDYFAI 652
Query: 629 EIDEEGN----LIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFY 684
++D+ N + +P L+ +VP LE LP I L V++D+E+ F ++ + +
Sbjct: 653 KLDQLENGRLHITEIPSLVHYFVPQLEKLPFLIATLVLNVDYDDEQNTFRTICRAIGDLF 712
Query: 685 SIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLA 744
++ +I+ + +S + WK ++ ++ ++ +PP+HF + G I QLA
Sbjct: 713 TLDTNFITLDKKISAFSA-------TPWKTLIKEVLMPLVKRKFIPPEHFKQAGVIRQLA 765
Query: 745 NLPDLYKVFERC 756
+ DLYKVFERC
Sbjct: 766 DSHDLYKVFERC 777
>gi|13517948|gb|AAK29067.1|AF346620_1 (AF346620) MLH1 [Trypanosoma brucei]
Length = 887
Score = 304 bits (779), Expect = 2e-81
Identities = 153/359 (42%), Positives = 230/359 (63%), Gaps = 25/359 (6%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I RL E V+NRIAAGEV+QRP+ A+KE++EN LDA ST IQV+V++GGL+L+Q+ D+G G
Sbjct: 4 IERLPEDVINRIAAGEVVQRPSAALKELLENSLDAGSTCIQVVVQDGGLELLQVTDDGHG 63
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
IR DL ++CER+ TSKL++F++L +I ++GFRGEAL SIS+VA VT+TT + A+R
Sbjct: 64 IRFGDLPLLCERYATSKLRAFDELNNIRSFGFRGEALCSISYVARVTVTTMRHNDTVAWR 123
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
Y DG+++ PKPCAGN GT I E +FYN A RR+A PSEE ++ +VV RY++
Sbjct: 124 CHYVDGRMQEEPKPCAGNPGTCIRAEKMFYNAAVRRRAFSRPSEECSRVEDVVSRYALAF 183
Query: 188 AGISFSVKKQGETVADVRT----LP-NASTVDNIRSIFGNAVSRELIEIGCEDKTLA--- 239
++FS ++ +VA V P +++T+ NIR +G V+ L E+ C ++ +
Sbjct: 184 PSVAFSCRRSDGSVAGVTKNCVCFPKDSNTLANIRQHWGGEVASRLCEVRCTGESPSEDN 243
Query: 240 -----------------FKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAA 282
F + GY S+ + +K +F+N+RLV+ST++R+A++ VY+
Sbjct: 244 CTPESVLATSGPSGEGRFLITGYTSDITLASRKSYLCVFVNNRLVDSTAIRRALDAVYSG 303
Query: 283 YLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSR 341
L + PF L + + P VDVN+HPTKHEV L EE I+ ++ + ++ L S + R
Sbjct: 304 VLVRGNRPFTVLFVTVPPDRVDVNIHPTKHEVCLLDEEIIVSQLSECVQGALQASAARR 362
Score = 95.5 bits (236), Expect = 2e-18
Identities = 79/276 (28%), Positives = 129/276 (46%), Gaps = 34/276 (12%)
Query: 503 LTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQ 562
LTSV ++ I + + + N ++VG + AQ T LY++++ +L + YQ
Sbjct: 624 LTSVSTIVSNIRAGTSQTAQSLFQNLAYVGVLKGHLFFAQSGTTLYVVDSLRLVRHVVYQ 683
Query: 563 ILIYDFANFGV-----LRLSEPAPLFDLAMLALDS----PESGWTEEDGPKEGLAEYIVE 613
+ +A + L EP L DL AL + P S + GP L+ +
Sbjct: 684 RIFLRWATPSLSTVPQLSFEEPIHLSDLLSFALQNDVQLPPSQKRADGGPGSLLSR-LGR 742
Query: 614 FLKKKAEMLADYFSLEIDEEGNLIGLPLLI-DNYVPPLEGLPIFILRLATEVNWDE-EKE 671
L ML DYF++EI +G+LI LPL + ++ PPL +P+FI RLA EV ++ E E
Sbjct: 743 RLCNWRYMLQDYFAVEISADGHLIALPLSMGTSWPPPLRAVPLFIWRLAAEVPYNAGEIE 802
Query: 672 CFESLSKECA-MFYSIR--KQYISEESTLSGQQSEVP--------GSIPNSWKWTVEHIV 720
CF ++++ A Y ++ ++ +Q +VP G +P + T
Sbjct: 803 CFTAIARHIAETLYGVQLHSSWLPNVIKDGIRQDDVPPFCDAIRFGLLPCATNSTF---- 858
Query: 721 YKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
+PP DG + + ++ +LYKVFERC
Sbjct: 859 -------FVPPCDALVDGTVQAVVSVDELYKVFERC 887
>gi|1465764|gb|AAC52672.1| (U60872) similar to human MLH1 on chromosome 3p21 [Mus musculus]
Length = 151
Score = 302 bits (773), Expect = 8e-81
Identities = 145/151 (96%), Positives = 150/151 (99%)
Query: 1 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ 60
M+FVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKST+IQV+VKEGGLKLIQ
Sbjct: 1 MAFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTNIQVVVKEGGLKLIQ 60
Query: 61 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
IQDNGTGIRKEDLDIVCERFTTSKLQ+FEDLASISTYGFRGEALASISHVAHVTITTKTA
Sbjct: 61 IQDNGTGIRKEDLDIVCERFTTSKLQTFEDLASISTYGFRGEALASISHVAHVTITTKTA 120
Query: 121 DGKCAYRASYSDGKLKAPPKPCAGNQGTQIT 151
DGKCAYRASYSDGKL+APPKPCAGNQGT IT
Sbjct: 121 DGKCAYRASYSDGKLQAPPKPCAGNQGTLIT 151
>gi|5107506|pdb|1BKN|A Chain A, Crystal Structure Of An N-Terminal 40kd Fragment Of E.
Coli Dna Mismatch Repair Protein Mutl
gi|5107507|pdb|1BKN|B Chain B, Crystal Structure Of An N-Terminal 40kd Fragment Of E.
Coli Dna Mismatch Repair Protein Mutl
Length = 352
Score = 207 bits (528), Expect = 2e-52
Identities = 122/339 (35%), Positives = 197/339 (57%), Gaps = 15/339 (4%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA +T I + ++ GG KLI+I+DNG G
Sbjct: 6 IQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCG 65
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I+K++L + R TSK+ S +DL +I + GFRGEALASIS V+ +T+T++TA+ + A++
Sbjct: 66 IKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQ 125
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
A Y++G+ + KP A GT + V DLFYN RRK L+ E+ I E++ R ++
Sbjct: 126 A-YAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALA 184
Query: 187 NAGISFSVKKQGETVADVRTLPNASTVD-NIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
++ ++ G+ V R +P + + +I G A + + I + L + G+
Sbjct: 185 RFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLR--GW 242
Query: 246 ISNANYSVKKC--IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+++ N++ I ++N R++ + AI L + P L LEI P V
Sbjct: 243 VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQV 302
Query: 304 DVNVHPTKHEVHF-----LHE---ESILERVQQHIESKL 334
DVNVHP KHEV F +H+ + +L +QQ +E+ L
Sbjct: 303 DVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPL 341
>gi|4929884|pdb|1B62|A Chain A, Mutl Complexed With Adp
Length = 349
Score = 207 bits (528), Expect = 2e-52
Identities = 122/339 (35%), Positives = 197/339 (57%), Gaps = 15/339 (4%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA +T I + ++ GG KLI+I+DNG G
Sbjct: 3 IQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I+K++L + R TSK+ S +DL +I + GFRGEALASIS V+ +T+T++TA+ + A++
Sbjct: 63 IKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQ 122
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
A Y++G+ + KP A GT + V DLFYN RRK L+ E+ I E++ R ++
Sbjct: 123 A-YAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALA 181
Query: 187 NAGISFSVKKQGETVADVRTLPNASTVD-NIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
++ ++ G+ V R +P + + +I G A + + I + L + G+
Sbjct: 182 RFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLR--GW 239
Query: 246 ISNANYSVKKC--IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+++ N++ I ++N R++ + AI L + P L LEI P V
Sbjct: 240 VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQV 299
Query: 304 DVNVHPTKHEVHF-----LHE---ESILERVQQHIESKL 334
DVNVHP KHEV F +H+ + +L +QQ +E+ L
Sbjct: 300 DVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPL 338
>gi|5542073|pdb|1B63|A Chain A, Mutl Complexed With Adpnp
Length = 333
Score = 207 bits (526), Expect = 5e-52
Identities = 119/331 (35%), Positives = 191/331 (56%), Gaps = 7/331 (2%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA +T I + ++ GG KLI+I+DNG G
Sbjct: 5 IQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCG 64
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I+K++L + R TSK+ S +DL +I + GFRGEALASIS V+ +T+T++TA+ + A++
Sbjct: 65 IKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQ 124
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
A Y++G+ + KP A GT + V DLFYN RRK L+ E+ I E++ R ++
Sbjct: 125 A-YAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALA 183
Query: 187 NAGISFSVKKQGETVADVRTLPNASTVD-NIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
++ ++ G+ V R +P + + +I G A + + I + L + G+
Sbjct: 184 RFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLR--GW 241
Query: 246 ISNANYSVKKC--IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+++ N++ I ++N R++ + AI L + P L LEI P V
Sbjct: 242 VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQV 301
Query: 304 DVNVHPTKHEVHFLHEESILERVQQHIESKL 334
DVNVHP KHEV F + + + Q + S L
Sbjct: 302 DVNVHPAKHEVRFHQSRLVHDFIYQGVLSVL 332
>gi|15602769|ref|NP_245841.1| MutL [Pasteurella multocida]
gi|13431695|sp|P57886|MUTL_PASMU DNA MISMATCH REPAIR PROTEIN MUTL
gi|12721220|gb|AAK02988.1| (AE006129) MutL [Pasteurella multocida]
Length = 617
Score = 206 bits (523), Expect = 1e-51
Identities = 119/340 (35%), Positives = 198/340 (58%), Gaps = 5/340 (1%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA +T IQ+ ++ GG LI+I+DNG G
Sbjct: 3 IKVLSPQLANQIAAGEVVERPASVVKELVENSLDAGATRIQIDIENGGSTLIRIRDNGIG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I K++L + R TSK+ S +DL +I + GFRGEALASIS V+ +T+T++ A A++
Sbjct: 63 IAKDELSLALARHATSKIASLDDLDNILSLGFRGEALASISSVSRLTLTSRPATQNEAWQ 122
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
+++ +P + GT + V +LF+N RRK L+ E+ I EV+ R ++
Sbjct: 123 VYAQGREMETTLQPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFAHIDEVIRRIALAK 182
Query: 188 AGISFSVKKQGETVADVRTLPNAS-TVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYI 246
ISF++ G+ V R+ + + + + +I G+ + +EI + L ++G++
Sbjct: 183 MAISFTLTHNGKIVRQYRSAHDRTQKLKRVAAICGDEFVQNALEIDWKHDDL--HLSGWV 240
Query: 247 SNANYS-VKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDV 305
+ +S + + +IN R+V + AI YA +L +P L ++++P +VDV
Sbjct: 241 AQPTFSRTQNDLSYCYINGRMVRDKIITHAIRQAYADFLSPEQYPAFVLFIDLNPNDVDV 300
Query: 306 NVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFT 345
NVHPTKHEV F + + + + Q I S L S + +Y T
Sbjct: 301 NVHPTKHEVRFHQQRLVHDFICQGI-SNALHSEQASLYQT 339
>gi|15804759|ref|NP_290800.1| enzyme in methyl-directed mismatch repair [Escherichia coli O157:H7
EDL933]
gi|15834400|ref|NP_313173.1| enzyme in methyl-directed mismatch repair [Escherichia coli
O157:H7]
gi|12519155|gb|AAG59366.1|AE005650_5 (AE005650) enzyme in methyl-directed mismatch repair [Escherichia
coli O157:H7 EDL933]
gi|13364623|dbj|BAB38569.1| (AP002568) enzyme in methyl-directed mismatch repair [Escherichia
coli O157:H7]
Length = 615
Score = 205 bits (522), Expect = 1e-51
Identities = 122/339 (35%), Positives = 197/339 (57%), Gaps = 15/339 (4%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA +T I + ++ GG KLI+I+DNG G
Sbjct: 3 IQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I+K++L + R TSK+ S +DL +I + GFRGEALASIS V+ +T+T++TA+ + A++
Sbjct: 63 IKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQ 122
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
A Y++G+ + KP A GT + V DLFYN RRK L+ E+ I E++ R ++
Sbjct: 123 A-YAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALA 181
Query: 187 NAGISFSVKKQGETVADVRTLPNASTVD-NIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
++ ++ G+ V R +P + + +I G A + + I + L + G+
Sbjct: 182 RFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLR--GW 239
Query: 246 ISNANYSVKKC--IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+++ N++ I ++N R++ + AI L + P L LEI P V
Sbjct: 240 VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQV 299
Query: 304 DVNVHPTKHEVHF-----LHE---ESILERVQQHIESKL 334
DVNVHP KHEV F +H+ + +L +QQ +E+ L
Sbjct: 300 DVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPL 338
>gi|16131992|ref|NP_418591.1| enzyme in methyl-directed mismatch repair [Escherichia coli K12]
gi|127552|sp|P23367|MUTL_ECOLI DNA MISMATCH REPAIR PROTEIN MUTL
gi|78712|pir||PH0853 methyl-directed mismatch repair protein mutL - Escherichia coli
gi|42067|emb|CAA77850.1| (Z11831) MutL Protein [Escherichia coli]
gi|537011|gb|AAA97066.1| (U14003) CG Site No. 470; alternate gene name mut-25 [Escherichia
coli]
gi|1790612|gb|AAC77127.1| (AE000489) enzyme in methyl-directed mismatch repair [Escherichia
coli K12]
Length = 615
Score = 205 bits (522), Expect = 1e-51
Identities = 122/339 (35%), Positives = 197/339 (57%), Gaps = 15/339 (4%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA +T I + ++ GG KLI+I+DNG G
Sbjct: 3 IQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I+K++L + R TSK+ S +DL +I + GFRGEALASIS V+ +T+T++TA+ + A++
Sbjct: 63 IKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQ 122
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
A Y++G+ + KP A GT + V DLFYN RRK L+ E+ I E++ R ++
Sbjct: 123 A-YAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALA 181
Query: 187 NAGISFSVKKQGETVADVRTLPNASTVD-NIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
++ ++ G+ V R +P + + +I G A + + I + L + G+
Sbjct: 182 RFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLR--GW 239
Query: 246 ISNANYSVKKC--IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+++ N++ I ++N R++ + AI L + P L LEI P V
Sbjct: 240 VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQV 299
Query: 304 DVNVHPTKHEVHF-----LHE---ESILERVQQHIESKL 334
DVNVHP KHEV F +H+ + +L +QQ +E+ L
Sbjct: 300 DVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPL 338
>gi|16272041|ref|NP_438240.1| DNA mismatch repair protein (mutL) [Haemophilus influenzae Rd]
gi|1171080|sp|P44494|MUTL_HAEIN DNA MISMATCH REPAIR PROTEIN MUTL
gi|1074023|pir||E64046 mismatch repair protein mutL - Haemophilus influenzae (strain Rd
KW20)
gi|1573016|gb|AAC21745.1| (U32692) DNA mismatch repair protein (mutL) [Haemophilus influenzae
Rd]
Length = 629
Score = 204 bits (520), Expect = 2e-51
Identities = 117/330 (35%), Positives = 193/330 (58%), Gaps = 6/330 (1%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA + IQ+ ++ GG LI+I+DNG G
Sbjct: 3 IKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNGCG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I KE+L + R TSK+ +DL +I + GFRGEALASIS V+ +T+T++T + A++
Sbjct: 63 IPKEELSLALARHATSKIADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEAWQ 122
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
Y+ G+ ++ KP + GT + V +LF+N RRK L+ E+ I EV+ R ++
Sbjct: 123 V-YAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFSHIDEVIRRIALT 181
Query: 187 NAGISFSVKKQGETVADVRTLPNAS-TVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
+F++ G+ + R + + + +I G+ + + I E K ++G+
Sbjct: 182 KFNTAFTLTHNGKIIRQYRPAEAINQQLKRVAAICGDDFVKNALRI--EWKHDDLHLSGW 239
Query: 246 ISNANYS-VKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVD 304
++ N+S + + +IN R+V + AI YA YLP + +P L ++++P +VD
Sbjct: 240 VATPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVD 299
Query: 305 VNVHPTKHEVHFLHEESILERVQQHIESKL 334
VNVHPTKHEV F + I + + + I L
Sbjct: 300 VNVHPTKHEVRFHQQRLIHDFIYEGISHAL 329
>gi|15794549|ref|NP_284371.1| DNA mismatch repair protein [Neisseria meningitidis Z2491]
gi|11280242|pir||C81860 DNA mismatch repair protein NMA1655 [imported] - Neisseria
meningitidis (group A strain Z2491)
gi|7380297|emb|CAB84883.1| (AL162756) DNA mismatch repair protein [Neisseria meningitidis
Z2491]
Length = 658
Score = 202 bits (513), Expect = 1e-50
Identities = 115/310 (37%), Positives = 182/310 (58%), Gaps = 7/310 (2%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I L + +VN+IAAGEV++RPANA+KE++EN +DA +T+I V + GG++LI++ DNG+G
Sbjct: 4 IAALPDHLVNQIAAGEVVERPANALKEIVENSIDAGATAIDVELDGGGIRLIRVSDNGSG 63
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I +D+++ R TSK+++ DL +++ GFRGE LASI+ V+ +T+T++ D A +
Sbjct: 64 IHPDDIELALHRHATSKIKTLNDLEHVASMGFRGEGLASIASVSRLTLTSRQEDSSHATQ 123
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
DGKL + P A GT I +LF+N RRK LK+ + EY ++ R ++ +
Sbjct: 124 VKAEDGKLSS-PTAAAHPVGTTIEAAELFFNTPARRKFLKSENTEYAHCATMIERLALAH 182
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYIS 247
I+FS+K+ G+ V LP S + I +I G+ +EI + + A ++ G I+
Sbjct: 183 PHIAFSLKRDGKQVF---KLPAQSLHERIAAIVGDDFQTASLEI--DSGSGALRLYGAIA 237
Query: 248 NANYSVKKC-IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVN 306
++ K F+NHR V + A++ Y L P L L++ P+ VDVN
Sbjct: 238 KPTFAKGKTDKQYCFVNHRFVRDKVMLHAVKQAYRDVLHNALTPAFVLFLDLPPEAVDVN 297
Query: 307 VHPTKHEVHF 316
VHPTK E+ F
Sbjct: 298 VHPTKTEIRF 307
>gi|14194230|gb|AAK56306.1|AF378369_2 (AF378369) DNA mismatch repair protein MutL [Staphylococcus aureus]
Length = 669
Score = 201 bits (512), Expect = 2e-50
Identities = 129/337 (38%), Positives = 197/337 (58%), Gaps = 15/337 (4%)
Query: 6 GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNG 65
G I+ L ++ N+IAAGEV++RP++ +KE++EN +DA +T I + V+E G++ I++ DNG
Sbjct: 2 GKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNG 61
Query: 66 TGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKT--ADGK 123
+GI EDL +V R TSKL EDL I T GFRGEALASIS VA VT+ T T A+G
Sbjct: 62 SGIEAEDLGLVFHRHATSKLDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGN 121
Query: 124 CAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRY 183
Y +G++ KP +GT I VE LFYN R K +K+ E GKI ++V R
Sbjct: 122 EIY---VENGEI-LNHKPAKAKKGTDILVESLFYNTPARLKYIKSLYTELGKITDIVNRM 177
Query: 184 SVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMN 243
++ + I ++ G+T+ + T + T + + I+G V+R+L+ I + T + +
Sbjct: 178 AMSHPDIRIALISDGKTM--LSTNGSGRTNEVMAEIYGMKVARDLVHISGD--TSDYHIE 233
Query: 244 GYISNANYS-VKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQN 302
G+++ +S K +FIN R +++ L KAI Y L P Y+++E+ P
Sbjct: 234 GFVAKPEHSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPIL 293
Query: 303 VDVNVHPTKHEVHFLHEES----ILERVQQHIESKLL 335
VDVNVHPTK EV EE I+ ++Q+ + ++L
Sbjct: 294 VDVNVHPTKLEVRLSKEEQLYQLIVSKIQEAFKDRIL 330
>gi|16120706|ref|NP_404019.1| DNA mismatch repair protein [Yersinia pestis]
gi|15978469|emb|CAC89230.1| (AJ414142) DNA mismatch repair protein [Yersinia pestis]
Length = 635
Score = 201 bits (512), Expect = 2e-50
Identities = 121/336 (36%), Positives = 197/336 (58%), Gaps = 8/336 (2%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA +T I + ++ GG KLI+I+DNG G
Sbjct: 3 IQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I K+DL + R TSK+ S EDL +I + GFRGEALASIS V+ + +T++TA+ A++
Sbjct: 63 ISKDDLALALARHATSKISSLEDLEAILSMGFRGEALASISSVSRLILTSRTAEQSEAWQ 122
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
A Y++G+ + KP A G+ + V DLFYN RRK ++ E+G I EVV R ++
Sbjct: 123 A-YAEGRDMAVTIKPAAHPVGSTLEVLDLFYNTPARRKFMRTEKTEFGHIDEVVRRIALA 181
Query: 187 NAGISFSVKKQGETVADVRTLPN-ASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
++ ++ G+ + R P+ A + SI G A + + I + L ++G+
Sbjct: 182 RFDVAINLNHNGKLIRQYRAAPDPAQHERRLASICGPAFLQHALAIAWQHGDL--NIHGW 239
Query: 246 ISN--ANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+++ A++++ + + ++N+R++ + AI Y L P L L+I P V
Sbjct: 240 VADPAASHTLSEMQY-CYVNNRMMRDRLINHAIRQAYQDRLNDAQQPAYVLYLDIDPHQV 298
Query: 304 DVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNS 339
DVNVHP KHEV F + + + Q + + L +N+
Sbjct: 299 DVNVHPAKHEVRFHQARLVHDFIYQAVTAVLQQTNA 334
>gi|15924287|ref|NP_371821.1| DNA mismatch repair protein [Staphylococcus aureus subsp. aureus
Mu50]
gi|15926879|ref|NP_374412.1| DNA mismatch repair protein [Staphylococcus aureus subsp. aureus
N315]
gi|13701096|dbj|BAB42391.1| (AP003133) DNA mismatch repair protein [Staphylococcus aureus
subsp. aureus N315]
gi|14247067|dbj|BAB57459.1| (AP003361) DNA mismatch repair protein [Staphylococcus aureus
subsp. aureus Mu50]
Length = 669
Score = 201 bits (512), Expect = 2e-50
Identities = 129/337 (38%), Positives = 197/337 (58%), Gaps = 15/337 (4%)
Query: 6 GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNG 65
G I+ L ++ N+IAAGEV++RP++ +KE++EN +DA +T I + V+E G++ I++ DNG
Sbjct: 2 GKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNG 61
Query: 66 TGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKT--ADGK 123
+GI EDL +V R TSKL EDL I T GFRGEALASIS VA VT+ T T A+G
Sbjct: 62 SGIEAEDLGLVFHRHATSKLDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGN 121
Query: 124 CAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRY 183
Y +G++ KP +GT I VE LFYN R K +K+ E GKI ++V R
Sbjct: 122 EIY---VENGEI-LNHKPAKAKKGTDILVESLFYNTPARLKYIKSLYTELGKITDIVNRM 177
Query: 184 SVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMN 243
++ + I ++ G+T+ + T + T + + I+G V+R+L+ I + T + +
Sbjct: 178 AMSHPDIRIALISDGKTM--LSTNGSGRTNEVMAEIYGMKVARDLVHISGD--TSDYHIE 233
Query: 244 GYISNANYS-VKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQN 302
G+++ +S K +FIN R +++ L KAI Y L P Y+++E+ P
Sbjct: 234 GFVAKPEHSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPIL 293
Query: 303 VDVNVHPTKHEVHFLHEES----ILERVQQHIESKLL 335
VDVNVHPTK EV EE I+ ++Q+ + ++L
Sbjct: 294 VDVNVHPTKLEVRLSKEEQLYQLIVSKIQEAFKDRIL 330
>gi|15895111|ref|NP_348460.1| DNA mismatch repair enzyme, MutL [Clostridium acetobutylicum]
gi|15024811|gb|AAK79800.1|AE007692_8 (AE007692) DNA mismatch repair enzyme, MutL [Clostridium
acetobutylicum]
Length = 622
Score = 201 bits (510), Expect = 3e-50
Identities = 116/318 (36%), Positives = 184/318 (57%), Gaps = 6/318 (1%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I L E N+IAAGEV++RP + +KE++EN +DA + +I + ++ GG LI++ D+G G
Sbjct: 3 INILSEDTSNKIAAGEVVERPFSVVKELVENSIDAGAKTINIEIENGGRTLIKVLDDGYG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I K+D++ TSK+ +D+ SI+T GFRGEAL SI+ V+ T+ ++T + +
Sbjct: 63 IDKDDIEKAFMPHATSKISKLQDIYSINTLGFRGEALPSIASVSKTTLKSRTKENEFGRE 122
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
S S G + K C N GT I V DLFYN+ R K LK+ ++E I ++V R ++ +
Sbjct: 123 ISISGGSVDY-IKDCGTNIGTHIEVRDLFYNVPAREKFLKSTAKEASSISDIVNRLALAH 181
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYIS 247
+ ISF + G+ V + T + +D IR+I+G + +I E T ++GY+
Sbjct: 182 SEISFRLINNGKRV--ITTYATDNLIDTIRAIYGKKICDNVISF--ERHTDLVSVHGYVG 237
Query: 248 NANYSV-KKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVN 306
NA S + +FIN R +++ + A+E +++ N PF + L+I P+ VDVN
Sbjct: 238 NAEISRGSRNNQSIFINKRYIKNKLITAAVENAVKSFMMINKFPFFIIFLDIFPEFVDVN 297
Query: 307 VHPTKHEVHFLHEESILE 324
VHPTK EV F +E I +
Sbjct: 298 VHPTKSEVKFQNERDIFK 315
>gi|7328294|emb|CAB82461.1| (AJ131755) DNA mismatch repair protein [Staphylococcus aureus]
Length = 468
Score = 200 bits (509), Expect = 4e-50
Identities = 129/337 (38%), Positives = 197/337 (58%), Gaps = 15/337 (4%)
Query: 6 GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNG 65
G I+ L ++ N+IAAGEV++RP++ +KE++EN +DA +T I + V+E G++ I++ DNG
Sbjct: 2 GKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNG 61
Query: 66 TGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKT--ADGK 123
+GI EDL +V R TSKL EDL I T GFRGEALASIS VA VT+ T T A+G
Sbjct: 62 SGIEAEDLGLVFHRHATSKLDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGN 121
Query: 124 CAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRY 183
Y +G++ KP +GT I VE LFYN R K +K+ E GKI ++V R
Sbjct: 122 EIY---VENGEI-LNHKPAKAKKGTDILVESLFYNTPARLKYIKSLYTELGKITDIVNRM 177
Query: 184 SVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMN 243
++ + I ++ G+T+ + T + T + + I+G V+R+L+ I + T + +
Sbjct: 178 AMSHPDIRIALISDGKTM--LSTNGSGRTNEVMAEIYGMKVARDLVHISGD--TSDYHIE 233
Query: 244 GYISNANYS-VKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQN 302
G+++ +S K +FIN R +++ L KAI Y L P Y+++E+ P
Sbjct: 234 GFVAKPEHSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPIL 293
Query: 303 VDVNVHPTKHEVHFLHEES----ILERVQQHIESKLL 335
VDVNVHPTK EV EE I+ ++Q+ + ++L
Sbjct: 294 VDVNVHPTKLEVRLSKEEQLYQLIVSKIQEAFKDRIL 330
>gi|15614931|ref|NP_243234.1| DNA mismatch repair protein [Bacillus halodurans]
gi|10174988|dbj|BAB06087.1| (AP001515) DNA mismatch repair protein [Bacillus halodurans]
Length = 637
Score = 200 bits (508), Expect = 5e-50
Identities = 124/351 (35%), Positives = 197/351 (55%), Gaps = 16/351 (4%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I +LD+ + N+IAAGEV++RPA+ +KE++EN LDA S I + V+ GGL I++ D+G G
Sbjct: 4 IIKLDDHLSNKIAAGEVVERPASVVKELVENALDANSRKITIEVEAGGLDRIRVIDDGDG 63
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I +ED++ R TSK+++ +DL I+T GFRGEAL SI+ V+HV I T T G
Sbjct: 64 IEREDVETAFFRHATSKIKTDKDLFQIATLGFRGEALPSIASVSHVQIKTSTG-GDGGTE 122
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
G +K G +GT +TV LFYN R K +K E G I +VV R ++ +
Sbjct: 123 MVLEGGVIKKIGSTAMG-KGTDLTVTQLFYNTPARLKYVKTVHTELGNISDVVNRLALAH 181
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYIS 247
+SF + G+ V +RT N + I +I+G V+++++ + E T+ F ++G+ +
Sbjct: 182 PYVSFQLFHNGKNV--LRTSGNGDQLQVIAAIYGRTVAKQMVPLSGE--TIDFTVSGFAA 237
Query: 248 NANYSVKKCIFL-LFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVN 306
+ ++ L +N R + + +L KAI+ + LP +P +++E+ PQ +DVN
Sbjct: 238 KPEVTRASRQYMSLLVNGRYIRNVALSKAIQQGFHTLLPIGRYPIAIVNIELDPQLIDVN 297
Query: 307 VHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSG 357
VHP+K EV EE + V + IE R + + L+P P+G
Sbjct: 298 VHPSKLEVRVSKEEELCRLVTETIE---------RAFKKEQLIPEATKPTG 339
>gi|15677300|ref|NP_274454.1| mismatch repair protein MutL [Neisseria meningitidis MC58]
gi|11280243|pir||B81084 mismatch repair protein MutL NMB1442 [imported] - Neisseria
meningitidis (group B strain MD58)
gi|7226683|gb|AAF41803.1| (AE002493) mismatch repair protein MutL [Neisseria meningitidis
MC58]
Length = 658
Score = 200 bits (508), Expect = 5e-50
Identities = 115/320 (35%), Positives = 184/320 (56%), Gaps = 7/320 (2%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I L + +VN+IAAGEV++RPANA+KE++EN +DA +T+I+V + GG++LI++ DNG G
Sbjct: 4 IAALPDHLVNQIAAGEVVERPANALKEIVENSIDAGATAIEVELAGGGIRLIRVSDNGGG 63
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I +D+++ R TSK+++ DL +++ GFRGE LASI+ V+ +T+T++ D A +
Sbjct: 64 IHPDDIELALHRHATSKIKTLNDLEHVASMGFRGEGLASIASVSRLTLTSRQNDSSHATQ 123
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
DGKL + P A GT I +LF+N RRK LK+ + EY ++ R ++ +
Sbjct: 124 VKAEDGKLSS-PTAAAHPVGTTIEAAELFFNTPARRKFLKSENTEYAHCATMLERLALAH 182
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYIS 247
I+FS+K+ G+ V LP S + I +I G + +G + A ++ G I+
Sbjct: 183 PHIAFSLKRDGKQVF---KLPAQSLHERIAAIVGEDF--QTASLGIDSGNGALRLYGAIA 237
Query: 248 NANYSVKKC-IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVN 306
++ K F+NHR V + A++ Y L P L L++ P+ VDVN
Sbjct: 238 KPTFAKGKTDKQYCFVNHRFVRDKVMLHAVKQAYRDVLHNALTPAFVLFLDLPPEAVDVN 297
Query: 307 VHPTKHEVHFLHEESILERV 326
VHPTK E+ F + + + V
Sbjct: 298 VHPTKTEIRFRDSQQVHQLV 317
>gi|14577936|gb|AAK68861.1| (AF091119) HexB [Lactococcus lactis]
Length = 323
Score = 200 bits (508), Expect = 5e-50
Identities = 121/333 (36%), Positives = 188/333 (56%), Gaps = 18/333 (5%)
Query: 6 GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNG 65
G I L+E + N+IAAGEV++RPA +KE++EN +DA S+ I + V+E GL+LI++ DNG
Sbjct: 2 GKIIELNEALANQIAAGEVVERPATVVKELVENSIDAGSSKIIINVEEAGLRLIEVIDNG 61
Query: 66 TGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCA 125
G+ KED+ + R TSK++ DL I T GFRGEAL SI+ V+ +TI T TA+ +
Sbjct: 62 LGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIASVSQMTIETSTAEEESG 121
Query: 126 YRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSV 185
+ G ++ +P A GT+I+V +LFYN R K +K+ E I +++ R S+
Sbjct: 122 TKLVAKGGNIET-LEPLAKRVGTKISVANLFYNTPARLKYIKSLQAELSHITDIINRLSL 180
Query: 186 HNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
+ ISF++ +G+ ++T N I +I+G ++++ +I D L F++ GY
Sbjct: 181 AHPEISFTLVNEGKEF--LKTAGNGDLRQVIAAIYGIGTAKKMRQIKGSD--LDFELTGY 236
Query: 246 IS-------NANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEI 298
+S N NY + IN R +++ L +AI Y L PF LS++I
Sbjct: 237 VSLPELTRANRNY------ITILINGRFIKNFLLNRAILEGYGNRLMVGRFPFAILSIKI 290
Query: 299 SPQNVDVNVHPTKHEVHFLHEESILERVQQHIE 331
P DVNVHPTK EV E ++ + + I+
Sbjct: 291 DPTLADVNVHPTKQEVRLSKERELMALISKAID 323
>gi|15674190|ref|NP_268365.1| DNA mismatch repair protein MutL [Lactococcus lactis subsp. lactis]
gi|12725273|gb|AAK06306.1|AE006449_12 (AE006449) DNA mismatch repair protein MutL [Lactococcus lactis
subsp. lactis]
Length = 695
Score = 200 bits (508), Expect = 5e-50
Identities = 122/338 (36%), Positives = 191/338 (56%), Gaps = 18/338 (5%)
Query: 4 VAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQD 63
+ G I L+E + N+IAAGEV++RPA+ +KE++EN +DA S+ I + V+E GL+LI++ D
Sbjct: 39 IVGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVID 98
Query: 64 NGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGK 123
NG G+ KED+ + R TSK++ DL I T GFRGEAL SI+ V+ +TI T TA+ +
Sbjct: 99 NGLGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIASVSQMTIETSTAEEE 158
Query: 124 CAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRY 183
+ G ++ +P A GT+I+V +LFYN R K +K+ E I +++ R
Sbjct: 159 SGTKLVAKGGNIET-LEPLAKRVGTKISVANLFYNTPARLKYIKSLQAELSHITDIINRL 217
Query: 184 SVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMN 243
S+ + ISF++ +G+ ++T N I +I+G ++++ +I D L F++
Sbjct: 218 SLAHPEISFTLVNEGKEF--LKTAGNGDLRQVIAAIYGIGTAKKMRQIKGSD--LDFELT 273
Query: 244 GYIS-------NANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSL 296
GY+S N NY + IN R +++ L +AI Y L PF LS+
Sbjct: 274 GYVSLPELTRANRNY------ITILINGRFIKNFLLNRAILEGYGNRLMVGRFPFAILSI 327
Query: 297 EISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKL 334
+I P DVNVHPTK EV E ++ + + I+ L
Sbjct: 328 KIDPTLADVNVHPTKQEVRLSKERELMALISKAIDEAL 365
>gi|16505486|emb|CAD06836.1| (AL627283) DNA mismatch repair protein [Salmonella enterica subsp.
enterica serovar Typhi]
Length = 618
Score = 199 bits (507), Expect = 6e-50
Identities = 119/339 (35%), Positives = 193/339 (56%), Gaps = 15/339 (4%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA +T + + ++ GG KLI+I+DNG G
Sbjct: 3 IQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I+KE+L + R TSK+ S +DL +I + GFRGEALASIS V+ +T+T++TA+ A++
Sbjct: 63 IKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQ 122
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
A Y++G+ + KP A GT + V DLFYN RRK ++ E+ I E++ R ++
Sbjct: 123 A-YAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALA 181
Query: 187 NAGISFSVKKQGETVADVRTLP-NASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
++ ++ G+ V R + + + +I G + + I + L + G+
Sbjct: 182 RFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLR--GW 239
Query: 246 ISNANYSVKKC--IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+++ N++ I ++N R++ + AI L + P L LEI P V
Sbjct: 240 VADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQV 299
Query: 304 DVNVHPTKHEVHF-----LHE---ESILERVQQHIESKL 334
DVNVHP KHEV F +H+ + +L +QQ E+ L
Sbjct: 300 DVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTL 338
>gi|15640372|ref|NP_229999.1| DNA mismatch repair protein MutL [Vibrio cholerae]
gi|11280239|pir||A82334 DNA mismatch repair protein MutL VC0345 [imported] - Vibrio
cholerae (group O1 strain N16961)
gi|9654761|gb|AAF93518.1| (AE004123) DNA mismatch repair protein MutL [Vibrio cholerae]
Length = 653
Score = 199 bits (507), Expect = 7e-50
Identities = 119/333 (35%), Positives = 195/333 (57%), Gaps = 10/333 (3%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
IR L + N+IAAGEV++RPA+ +KE++EN LDA +T I + +++GG KLI+I+DNG+G
Sbjct: 3 IRILPARLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDLEKGGAKLIRIRDNGSG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I K++L + R TSK+ + +DL +I + GFRGEALASIS V+ +T+T++T + A+
Sbjct: 63 IDKDELGLALSRHATSKIHTLDDLEAIMSLGFRGEALASISSVSRLTLTSRTVAQEEAWS 122
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
A YS+G+ + +P A GT + V DLF+N RRK L+ E+ I E++ R ++
Sbjct: 123 A-YSEGRDMAVKLQPAAHPVGTTVEVLDLFFNTPARRKFLRTEKTEFTHIDELLKRIALS 181
Query: 187 NAGISFSVKKQGETVADVR---TLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMN 243
+SF+++ G+ V R TLP + ++ GN + ++ I E + L K++
Sbjct: 182 RFDVSFTLRHNGKIVRQYRAATTLPQQEK--RLAAVCGNPFVQHMLRIELEHQGL--KLH 237
Query: 244 GYISNANYSVKKC-IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQN 302
G+I+ + ++ + ++N R++ + AI Y L + L +E+ P
Sbjct: 238 GWITTPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRVDQFATYVLFIELDPHQ 297
Query: 303 VDVNVHPTKHEVHFLHEESILERVQQHIESKLL 335
VDVNVHP KHEV F + + + Q + S L+
Sbjct: 298 VDVNVHPAKHEVRFHQARLVHDFIYQALSSALV 330
>gi|127553|sp|P14161|MUTL_SALTY DNA MISMATCH REPAIR PROTEIN MUTL
gi|96808|pir||A33588 mismatch repair protein mutL - Salmonella typhimurium
gi|154186|gb|AAA27166.1| (M29687) mismatch repair protein [Salmonella typhimurium]
gi|16422919|gb|AAL23179.1| (AE008904) enzyme in methyl-directed mismatch repair, stimulates
binding of Vsr and MutS to heteroduplex DNA [Salmonella
typhimurium LT2]
Length = 618
Score = 198 bits (504), Expect = 1e-49
Identities = 119/339 (35%), Positives = 193/339 (56%), Gaps = 15/339 (4%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ +KE++EN LDA +T + + ++ GG KLI+I+DNG G
Sbjct: 3 IQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I+KE+L + R TSK+ S +DL +I + GFRGEALASIS V+ +T+T++TA+ A++
Sbjct: 63 IKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQ 122
Query: 128 ASYSDGK-LKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVH 186
A Y++G+ + KP A GT + V DLFYN RRK ++ E+ I E++ R ++
Sbjct: 123 A-YAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALA 181
Query: 187 NAGISFSVKKQGETVADVRTLP-NASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY 245
++ ++ G+ V R + + + +I G + + I + L + G+
Sbjct: 182 RFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLR--GW 239
Query: 246 ISNANYSVKKC--IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNV 303
+++ N++ I ++N R++ + AI L + P L LEI P V
Sbjct: 240 VADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQV 299
Query: 304 DVNVHPTKHEVHF-----LHE---ESILERVQQHIESKL 334
DVNVHP KHEV F +H+ + +L +QQ E+ L
Sbjct: 300 DVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETAL 338
>gi|15600139|ref|NP_253633.1| DNA mismatch repair protein MutL [Pseudomonas aeruginosa]
gi|11348441|pir||F83028 DNA mismatch repair protein MutL PA4946 [imported] - Pseudomonas
aeruginosa (strain PAO1)
gi|9951226|gb|AAG08331.1|AE004907_9 (AE004907) DNA mismatch repair protein MutL [Pseudomonas
aeruginosa]
Length = 633
Score = 194 bits (492), Expect = 4e-48
Identities = 110/311 (35%), Positives = 175/311 (55%), Gaps = 4/311 (1%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L + N+IAAGEV++RPA+ KE++EN LDA S I V V++GG+KL++++D+G G
Sbjct: 7 IQLLSPRLANQIAAGEVVERPASVAKELLENSLDAGSRRIDVEVEQGGIKLLRVRDDGRG 66
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I +DL + R TSK++ EDL + + GFRGEALASIS VA +T+T++TAD A++
Sbjct: 67 IPADDLPLALARHATSKIRELEDLERVMSLGFRGEALASISSVARLTMTSRTADAGEAWQ 126
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
++ +P A GT + V DLF+N RRK L+ E+ + EV+ R ++
Sbjct: 127 VETEGRDMQPRVQPAAHPVGTSVEVRDLFFNTPARRKFLRAEKTEFDHLQEVIKRLALAR 186
Query: 188 AGISFSVKKQGETVADVRTLPNA-STVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYI 246
++F ++ G+T+ + + + + ++ G A + + I E L + G++
Sbjct: 187 FDVAFHLRHNGKTIFALHEARDELARARRVGAVCGQAFLEQALPIEVERNGL--HLWGWV 244
Query: 247 SNANYSVKKC-IFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDV 305
+S + + ++N R+V + A+ Y L HP L E+ P VDV
Sbjct: 245 GLPTFSRSQPDLQYFYVNGRMVRDKLVAHAVRQAYRDVLYNGRHPTFVLFFEVDPAVVDV 304
Query: 306 NVHPTKHEVHF 316
NVHPTKHEV F
Sbjct: 305 NVHPTKHEVRF 315
>gi|16413914|emb|CAC96672.1| (AL596168) DNA mismatch repair protein [Listeria innocua]
Length = 603
Score = 192 bits (488), Expect = 1e-47
Identities = 124/326 (38%), Positives = 189/326 (57%), Gaps = 9/326 (2%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I L + + N+IAAGEV++RPA+ +KE++EN +DA ST I ++V+E GL I I DNG+G
Sbjct: 5 IVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSG 64
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I +ED+ I R TSK+++ DL + T GFRGEAL SI+ V+H+T+ T T + K
Sbjct: 65 IEEEDVAIAFLRHATSKIKNEADLFRVHTLGFRGEALPSIASVSHLTLETSTGETK-GTT 123
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
S GK+ K +GTQI V LF+N R K LK+ E G I +++ R ++ +
Sbjct: 124 ISLEGGKI-IEQKSGHARKGTQIEVSQLFFNTPARLKYLKSLPTELGNITDILNRLALAH 182
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY-- 245
ISF G+ + ++T N I +I+G +++R+ I + E +L FK++GY
Sbjct: 183 PDISFRFSHNGKPL--LQTNGNGDLRQVIAAIYGVSIARKSIPVKAE--SLDFKISGYAV 238
Query: 246 ISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDV 305
+ N S + I + IN R +++ +L KAI+ Y LP P + L +E+ P VDV
Sbjct: 239 LPEVNRSNRNYISTI-INGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDV 297
Query: 306 NVHPTKHEVHFLHEESILERVQQHIE 331
NVHP K EV E+ + + + Q I+
Sbjct: 298 NVHPAKLEVRLSKEKELGQLISQMIK 323
>gi|16410833|emb|CAC99482.1| (AL591979) DNA mismatch repair protein [Listeria monocytogenes]
Length = 601
Score = 187 bits (474), Expect = 4e-46
Identities = 121/326 (37%), Positives = 187/326 (57%), Gaps = 9/326 (2%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I L + + N+IAAGEV++RPA+ +KE++EN +DA ST I ++V+E GL I I DNG+G
Sbjct: 5 IVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSG 64
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I +ED+ R TSK+++ DL + T GFRGEAL SI+ V+H+ + T T + K
Sbjct: 65 IEEEDVATAFLRHATSKIKNEADLFRVHTLGFRGEALPSIASVSHLAMETSTGETK-GTS 123
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
S GK+ K +GTQI V LF+N R K LK+ E G I +++ R ++ +
Sbjct: 124 ISLEGGKI-IEQKSGHARKGTQIEVSQLFFNTPARLKYLKSLPTELGNITDILNRLALAH 182
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGY-- 245
ISF G+ + ++T N I +I+G +++++ I + E +L FK++GY
Sbjct: 183 PDISFRFSHNGKPL--LQTNGNGDLRQVIAAIYGISIAKKSIPVKAE--SLDFKISGYAV 238
Query: 246 ISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDV 305
+ N S + I + IN R +++ +L KAI+ Y LP P + L +E+ P VDV
Sbjct: 239 LPEVNRSNRNYISTI-INGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDV 297
Query: 306 NVHPTKHEVHFLHEESILERVQQHIE 331
NVHP K EV E+ + + + Q I+
Sbjct: 298 NVHPAKLEVRLSKEKELGQLISQMIK 323
>gi|15675871|ref|NP_270045.1| putative DNA mismatch repair protein [Streptococcus pyogenes]
gi|13623105|gb|AAK34766.1| (AE006631) putative DNA mismatch repair protein [Streptococcus
pyogenes M1 GAS]
Length = 660
Score = 186 bits (473), Expect = 6e-46
Identities = 117/338 (34%), Positives = 187/338 (54%), Gaps = 26/338 (7%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I L E + N+IAAGEV++RPA+ +KE++EN +DAKS+ I V ++E GLK+IQ+ DNG G
Sbjct: 4 IIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEG 63
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
+ EDL + R TSK++S DL I T GFRGEAL S++ ++ +TI T T +
Sbjct: 64 MSHEDLPLSLRRHATSKIKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSL 123
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
+ G+++ + + GT+I VE+LFYN R K +K+ E I++VV R S+ +
Sbjct: 124 LIATGGEIET-LEAISTPTGTKIKVENLFYNTPARLKYMKSLQAELAHIVDVVNRLSLAH 182
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRS----IFGNAVSRELIEIGCEDKTLAFKMN 243
++F++ ++D R L S ++R I+G +++++ I D L F+++
Sbjct: 183 PEVAFTL------ISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNAD--LDFEVS 234
Query: 244 GYIS-------NANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSL 296
GY+S N NY + +N R +++ L +AI Y + L P + + +
Sbjct: 235 GYVSLPELTRANRNY------MTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDI 288
Query: 297 EISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKL 334
+I P DVNVHPTK EV E ++ + I L
Sbjct: 289 QIDPYLADVNVHPTKQEVRISKERELMALISTAISESL 326
>gi|15893284|ref|NP_360998.1| DNA mismatch repair protein MutL [Rickettsia conorii]
gi|15620505|gb|AAL03899.1| (AE008681) DNA mismatch repair protein MutL [Rickettsia conorii]
Length = 610
Score = 185 bits (469), Expect = 1e-45
Identities = 114/312 (36%), Positives = 176/312 (55%), Gaps = 6/312 (1%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+ L E+ +NRIAAGEVI+RPA+ +KE++EN +DA ST I +I++ G LI I D+G G
Sbjct: 3 IKFLSESTINRIAAGEVIERPASVVKELVENAVDASSTKIDIILERAGKNLIIISDDGIG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
+ ++L+I ER TTSK D +I+T+GFRGEAL SI+ ++ + IT+K D A++
Sbjct: 63 MTDKELEIAVERHTTSKFDE-SDFLNINTFGFRGEALPSIAAISKMLITSKKRDADKAFQ 121
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
G K N+GT+I + DLF+ R K L+ E ++VV + ++ +
Sbjct: 122 IKLIGGNEKQ-VTISVHNEGTKIEIRDLFFATPARLKFLRADKTELTATVDVVKKIALAH 180
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGC--EDKTLAFKMNGY 245
ISFS+ G+ + ++ N N++ + + + I+ + KT F + GY
Sbjct: 181 PKISFSLTHDGKNLLKLKG-QNKDAETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGY 239
Query: 246 ISNANYS-VKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVD 304
S+ Y+ LFIN+R V+ L+ A+ Y YL ++ +P + L+I PQ VD
Sbjct: 240 TSSPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPICAIFLQIDPQLVD 299
Query: 305 VNVHPTKHEVHF 316
VNVHP K EV F
Sbjct: 300 VNVHPAKAEVRF 311
>gi|15900110|ref|NP_344714.1| DNA mismatch repair protein HexB [Streptococcus pneumoniae TIGR4]
gi|15902204|ref|NP_357754.1| DNA mismatch repair protein [Streptococcus pneumoniae R6]
gi|14971640|gb|AAK74354.1| (AE007333) DNA mismatch repair protein HexB [Streptococcus
pneumoniae TIGR4]
gi|15457702|gb|AAK98964.1| (AE008399) DNA mismatch repair protein [Streptococcus pneumoniae
R6]
Length = 649
Score = 184 bits (466), Expect = 4e-45
Identities = 119/334 (35%), Positives = 182/334 (53%), Gaps = 18/334 (5%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I L E + N+IAAGEVI+RPA+ +KE++EN +DA S+ I + ++E GLK +QI DNG G
Sbjct: 4 IIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHG 63
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I +++++ R TSK+++ DL I T GFRGEAL SI+ V+ +T+ T DG
Sbjct: 64 IAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPSIASVSVLTLLT-AVDGASHGT 122
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
+ G P GT++ VEDLF+N R K +K+ E I+++V R + +
Sbjct: 123 KLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKYMKSQQAELSHIIDIVNRLGLAH 182
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYIS 247
ISFS+ G+ + RT I I+G ++++IEI E+ L F+++G++S
Sbjct: 183 PEISFSLISDGKEM--TRTAGTGQLRQAIAGIYGLVSAKKMIEI--ENSDLDFEISGFVS 238
Query: 248 -------NANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
N NY LFIN R +++ L +AI + + L P + + I P
Sbjct: 239 LPELTRANRNY------ISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDP 292
Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKL 334
DVNVHPTK EV E+ ++ V + I + L
Sbjct: 293 YLADVNVHPTKQEVRISKEKELMTLVSEAIANSL 326
>gi|123083|sp|P14160|HEXB_STRPN DNA MISMATCH REPAIR PROTEIN HEXB
gi|98033|pir||A33589 mismatch repair protein hexB [validated] - Streptococcus pneumoniae
gi|153657|gb|AAA88600.1| (M29686) mismatch repair protein [Streptococcus pneumoniae]
Length = 649
Score = 182 bits (462), Expect = 1e-44
Identities = 119/334 (35%), Positives = 181/334 (53%), Gaps = 18/334 (5%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I L E + N+IAAGEVI+RPA+ KE++EN +DA S+ I + ++E GLK +QI DNG G
Sbjct: 4 IIELPEMLANQIAAGEVIERPASVCKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHG 63
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I +++++ R TSK+++ DL I T GFRGEAL SI+ V+ +T+ T DG
Sbjct: 64 IAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPSIASVSVLTLLT-AVDGASHGT 122
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
+ G P GT++ VEDLF+N R K +K+ E I+++V R + +
Sbjct: 123 KLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKYMKSQQAELSHIIDIVNRLGLAH 182
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYIS 247
ISFS+ G+ + RT I I+G ++++IEI E+ L F+++G++S
Sbjct: 183 PEISFSLISDGKEM--TRTAGTGQLRQAIAGIYGLVSAKKMIEI--ENSDLDFEISGFVS 238
Query: 248 -------NANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
N NY LFIN R +++ L +AI + + L P + + I P
Sbjct: 239 LPELTRANRNY------ISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDP 292
Query: 301 QNVDVNVHPTKHEVHFLHEESILERVQQHIESKL 334
DVNVHPTK EV E+ ++ V + I + L
Sbjct: 293 YLADVNVHPTKQEVRISKEKELMTLVSEAIANSL 326
>gi|15617161|ref|NP_240374.1| DNA mismatch repair protein mutL [Buchnera sp. APS]
gi|11386926|sp|P57633|MUTL_BUCAI DNA MISMATCH REPAIR PROTEIN MUTL
gi|10039226|dbj|BAB13260.1| (AP001119) DNA mismatch repair protein mutL [Buchnera sp. APS]
Length = 584
Score = 181 bits (459), Expect = 2e-44
Identities = 114/332 (34%), Positives = 191/332 (57%), Gaps = 10/332 (3%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
IR L + ++I+AGE+I+RPA+ +KE+IEN +DA S +I +IV+ G + I ++D+G G
Sbjct: 3 IRILPSDLSSQISAGEIIERPASVVKEIIENSIDAGSKNINIIVENSGFQSIILKDDGCG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
I K+DL + TSK+ S DL ++T+GFRGEALASI V+ +T+ + T A +
Sbjct: 63 IDKKDLLLAVCHHATSKINSLSDLDKLTTFGFRGEALASIRAVSRLTLISCTRFNDVAAK 122
Query: 128 ASYSDG--KLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSV 185
Y +G +P A +GT I V++LFYNI R K LKN E+ KI EVV + ++
Sbjct: 123 I-YLEGFCSKNIILQPIAHPEGTTIIVDNLFYNIPVRLKFLKNKKLEFSKICEVVKKIAL 181
Query: 186 HNAGISFSVKKQGETVADVRTLPN-ASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNG 244
+ I+FS+K + + ++ N + ++ ++ IF + E +EI ++K + G
Sbjct: 182 SHFYINFSLKHNNKLITQYNSINNRKNKINRLKDIFDTLDTSEFLEI--KEKKYRMVLFG 239
Query: 245 YISNA-NYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPF-LYLSLEISPQN 302
+IS+ N+ K I ++N+R + + A+ Y+ K F LYL++E N
Sbjct: 240 WISHPYNFKKIKNIQYCYVNNRYLYNNIFVNAVRAAYSKIEQKKNISFVLYLTIE--SFN 297
Query: 303 VDVNVHPTKHEVHFLHEESILERVQQHIESKL 334
+D+N+HPTK+E+ F + + + + + + S L
Sbjct: 298 IDINIHPTKNEIKFHNPDVVYTFIYEAVFSYL 329
>gi|15964569|ref|NP_384922.1| PROBABLE DNA MISMATCH REPAIR PROTEIN [Sinorhizobium meliloti]
gi|15073747|emb|CAC45388.1| (AL591785) PROBABLE DNA MISMATCH REPAIR PROTEIN [Sinorhizobium
meliloti]
Length = 605
Score = 181 bits (458), Expect = 3e-44
Identities = 113/314 (35%), Positives = 170/314 (53%), Gaps = 15/314 (4%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I++L ET++N+IAAGEVI+RPA+A KE+IEN LDA +T I++ GG L+++ DNG G
Sbjct: 3 IKQLSETLINQIAAGEVIERPASAAKELIENALDAGATRIEIATAGGGKTLLRVTDNGIG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
+ DL++ R TSKL + LA I T GFRGEAL SI VA ++ITT+TA+ +
Sbjct: 63 MSPADLELAIRRHCTSKLN--DSLADIRTLGFRGEALPSIGSVARLSITTRTAEAREGAA 120
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
+ + G+ P +P A GT + V DLF+ R K +K+ E I EVV R ++
Sbjct: 121 ITVTGGR-SEPARPSAAIVGTVVEVRDLFFATPARLKFMKSEKAEAAAISEVVRRMAIAF 179
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDN----IRSIFGNAVSRELIEIGCEDKTLAFKMN 243
+ F + +D TL +T D+ + + G IEI E + ++
Sbjct: 180 PRVRFVLSG-----SDRTTLEFPATGDDRLARMAQVLGRDFRDNAIEIDAERE--GARLT 232
Query: 244 GYISNANYSVKKCI-FLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQN 302
G+ ++ + F+N R V+ + A+ YA +P+ +P LS+ + P
Sbjct: 233 GFAGVPTFNRGNSLQQYAFVNGRPVQDKLIMSALRAAYAETIPQGRYPIAVLSITLDPAL 292
Query: 303 VDVNVHPTKHEVHF 316
VDVNVHP K +V F
Sbjct: 293 VDVNVHPAKSDVRF 306
>gi|15888043|ref|NP_353724.1| AGR_C_1260p [Agrobacterium tumefaciens]
gi|15155663|gb|AAK86509.1| (AE008004) AGR_C_1260p [Agrobacterium tumefaciens]
Length = 628
Score = 177 bits (449), Expect = 3e-43
Identities = 121/316 (38%), Positives = 168/316 (52%), Gaps = 19/316 (6%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I++L ET++N+IAAGEVI+RP++A KE++EN +DA +T I++ GG L++I DNG+G
Sbjct: 25 IKQLSETLINQIAAGEVIERPSSATKELVENAIDAGATRIEIATAGGGKGLVRITDNGSG 84
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
+ DL++ R TSK+ + L I T GFRGEAL SI VA +TIT++ +
Sbjct: 85 MSPADLELAVRRHCTSKIST--TLDDIRTLGFRGEALPSIGSVAKLTITSRQQGAEQGSV 142
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
S + GK+ + +P A N GT + V DLF+ R K LK E I EVV R ++
Sbjct: 143 ISVTGGKV-SDVRPAASNAGTIVEVRDLFFATPARLKFLKTERAEAAAITEVVKRMAIAF 201
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDN----IRSIFGNAVSRELIEI--GCEDKTL-AF 240
I F + D TL ST D+ + I G IEI G ED TL F
Sbjct: 202 PHIRFVLSG-----TDRSTLEIPSTGDDHLARMAQILGAEFKDNAIEIDAGREDVTLTGF 256
Query: 241 KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISP 300
+ N S + +F+N R V+ L AI YA +P +P LS+ + P
Sbjct: 257 AGVPTFNRGNSSHQ----YVFVNGRPVQDKLLLSAIRGAYAETVPHGRYPVAVLSITLDP 312
Query: 301 QNVDVNVHPTKHEVHF 316
VDVNVHP K +V F
Sbjct: 313 AFVDVNVHPAKSDVRF 328
>gi|16078768|ref|NP_389587.1| mutL [Bacillus subtilis]
gi|1709188|sp|P49850|MUTL_BACSU DNA MISMATCH REPAIR PROTEIN MUTL
gi|7450493|pir||A69663 DNA mismatch repair mutL - Bacillus subtilis
gi|1002521|gb|AAB19236.1| (U27343) MutL [Bacillus subtilis]
gi|2634077|emb|CAB13578.1| (Z99112) mutL [Bacillus subtilis]
Length = 627
Score = 177 bits (449), Expect = 3e-43
Identities = 111/329 (33%), Positives = 183/329 (54%), Gaps = 8/329 (2%)
Query: 4 VAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQD 63
+A VI+ DE + N+IAAGEV++RPA+ +KE++EN +DA ST I++ ++E GL I++ D
Sbjct: 1 MAKVIQLSDE-LSNKIAAGEVVERPASVVKELVENAIDADSTVIEIDIEEAGLASIRVLD 59
Query: 64 NGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGK 123
NG G+ ED R TSK++ DL + T GFRGEAL SI+ V+H+ ITT T +G
Sbjct: 60 NGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPSIASVSHLEITTSTGEG- 118
Query: 124 CAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRY 183
A G + +GT+I V +LF+N R K +K E G I +VV R
Sbjct: 119 -AGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYMKTVHTELGNITDVVNRI 177
Query: 184 SVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMN 243
++ + +S ++ G+ + ++T N + +I+G AV+++++ + +L F++
Sbjct: 178 ALAHPEVSIRLRHHGKNL--LQTNGNGDVRHVLAAIYGTAVAKKMLPLHVS--SLDFEVK 233
Query: 244 GYISNANYS-VKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQN 302
GYI+ + + +N R +++ L KA+ Y LP HP ++ + + P
Sbjct: 234 GYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLPIGRHPITFIEITMDPIL 293
Query: 303 VDVNVHPTKHEVHFLHEESILERVQQHIE 331
VDVNVHP+K EV E + + ++ I+
Sbjct: 294 VDVNVHPSKLEVRLSKETELHDLIRDGIK 322
>gi|15642797|ref|NP_227838.1| DNA mismatch repair protein [Thermotoga maritima]
gi|7462367|pir||H72427 DNA mismatch repair protein - Thermotoga maritima (strain MSB8)
gi|4980506|gb|AAD35116.1|AE001690_10 (AE001690) DNA mismatch repair protein [Thermotoga maritima]
Length = 516
Score = 176 bits (447), Expect = 6e-43
Identities = 108/328 (32%), Positives = 183/328 (54%), Gaps = 9/328 (2%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+RL E++V +IAAGEVI P+ +KE++EN LDA++ I V ++ GG ++++ DNG G
Sbjct: 9 IKRLPESLVRKIAAGEVIHNPSFVLKELVENSLDAQADRIVVEIENGGKNMVRVSDNGIG 68
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
+ +E+ + E +TTSK++S EDL I TYGFRGEALASI V+ I TKT A +
Sbjct: 69 MTREEALLAIEPYTTSKIESEEDLHRIRTYGFRGEALASIVQVSRAKIVTKTEKDALATQ 128
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
+ GK++ + + GT + V DLF+N+ RRK+LK+ + E E+ R+ +
Sbjct: 129 LMIAGGKVEEISE-THRDTGTTVEVRDLFFNLPVRRKSLKSSAIELRMCREMFERFVLVR 187
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYIS 247
+ F G+ V + P + + + + I E++ ++ G +S
Sbjct: 188 NDVDFVFTSDGKI---VHSFPRTQNIFERALLILEDLRKGYITF--EEELSGLRIKGIVS 242
Query: 248 NANYS-VKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVN 306
+ + + ++N R V S L + + VY LPK ++P L +E++P+ +DVN
Sbjct: 243 SREVTRSSRTGEYFYVNGRFVVSEELHEVLMKVYD--LPKRSYPVAVLFIEVNPEELDVN 300
Query: 307 VHPTKHEVHFLHEESILERVQQHIESKL 334
+HP+K V FL+EE + + +++ ++ L
Sbjct: 301 IHPSKIVVKFLNEEKVKKSLEETLKRNL 328
>gi|8928224|sp|P74925|MUTL_THEMA DNA MISMATCH REPAIR PROTEIN MUTL
gi|1575786|gb|AAB09596.1| (U71053) DNA mismatch repair protein [Thermotoga maritima]
Length = 510
Score = 176 bits (447), Expect = 6e-43
Identities = 108/328 (32%), Positives = 183/328 (54%), Gaps = 9/328 (2%)
Query: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
I+RL E++V +IAAGEVI P+ +KE++EN LDA++ I V ++ GG ++++ DNG G
Sbjct: 3 IKRLPESLVRKIAAGEVIHNPSFVLKELVENSLDAQADRIVVEIENGGKNMVRVSDNGIG 62
Query: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
+ +E+ + E +TTSK++S EDL I TYGFRGEALASI V+ I TKT A +
Sbjct: 63 MTREEALLAIEPYTTSKIESEEDLHRIRTYGFRGEALASIVQVSRAKIVTKTEKDALATQ 122
Query: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHN 187
+ GK++ + + GT + V DLF+N+ RRK+LK+ + E E+ R+ +
Sbjct: 123 LMIAGGKVEEISE-THRDTGTTVEVRDLFFNLPVRRKSLKSSAIELRMCREMFERFVLVR 181
Query: 188 AGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYIS 247
+ F G+ V + P + + + + I E++ ++ G +S
Sbjct: 182 NDVDFVFTSDGKI---VHSFPRTQNIFERALLILEDLRKGYITF--EEELSGLRIKGIVS 236
Query: 248 NANYS-VKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVN 306
+ + + ++N R V S L + + VY LPK ++P L +E++P+ +DVN
Sbjct: 237 SREVTRSSRTGEYFYVNGRFVVSEELHEVLMKVYD--LPKRSYPVAVLFIEVNPEELDVN 294
Query: 307 VHPTKHEVHFLHEESILERVQQHIESKL 334
+HP+K V FL+EE + + +++ ++ L
Sbjct: 295 IHPSKIVVKFLNEEKVKKSLEETLKRNL 322
Database: nr
Posted date: Oct 28, 2001 1:00 AM
Number of letters in database: 251,575,206
Number of sequences in database: 791,492
Lambda K H
0.316 0.133 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 351,344,812
Number of Sequences: 791492
Number of extensions: 14336491
Number of successful extensions: 37576
Number of sequences better than 10.0: 174
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 37162
Number of HSP's gapped (non-prelim): 208
length of query: 756
length of database: 251,575,206
effective HSP length: 127
effective length of query: 629
effective length of database: 151,055,722
effective search space: 95014049138
effective search space used: 95014049138
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 75 (33.5 bits)
