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LOCUS AAC50285 756 aa PRI 29-NOV-1995
DEFINITION hMLH1.
ACCESSION AAC50285
PID g463989
VERSION AAC50285.1 GI:463989
DBSOURCE locus HSU07343 accession U07343.1
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 756)
AUTHORS Bronner,C.E., Baker,S.M., Morrison,P.T., Warren,G., Smith,L.G.,
Lescoe,M.K., Kane,M., Earibino,C., Lipford,J., Linblom,A.,
Tannergard,P., Bollag,R.J., Godwin,A.R., Ward,D.C.,
Nordenskjold,M., Fishel,R., Kolodner,R.D. and Liskay,R.M.
TITLE Mutation in the DNA mismatch repair gene homologue hMLH1 is
associated with hereditary non-polyposis colon cancer
JOURNAL Nature 368 (6468), 258-261 (1994)
MEDLINE 94195398
REFERENCE 2 (residues 1 to 756)
AUTHORS Morrison,P.T.
TITLE Direct Submission
JOURNAL Submitted (02-MAR-1994) Paul T. Morrison, Molecular Biology Core
Facility, Dana-Farber Cancer Institute, 44 Binney Street, Boston,
MA 002115, USA
COMMENT Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..756
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p22-23"
Protein 1..756
/product="hMLH1"
CDS 1..756
/gene="hMLH1"
/coded_by="U07343.1:22..2292"
/note="homolog of S. cerevisiae PMS1 (Swiss-Prot Accession
Number P14242), S. cerevisiae MLH1 (GenBank Accession
Number U07187), E. coli MUTL (Swiss-Prot Accession Number
P23367), Salmonella typhimurium MUTL (Swiss-Prot Accession
Number P14161) and Streptococcus pneumoniae (Swiss-Prot
Accession Number P14160)"
ORIGIN
1 msfvagvirr ldetvvnria ageviqrpan aikemiencl dakstsiqvi vkegglkliq
61 iqdngtgirk edldivcerf ttsklqsfed lasistygfr gealasishv ahvtittkta
121 dgkcayrasy sdgklkappk pcagnqgtqi tvedlfynia trrkalknps eeygkilevv
181 grysvhnagi sfsvkkqget vadvrtlpna stvdnirsif gnavsrelie igcedktlaf
241 kmngyisnan ysvkkcifll finhrlvest slrkaietvy aaylpknthp flylsleisp
301 qnvdvnvhpt khevhflhee silervqqhi eskllgsnss rmyftqtllp glagpsgemv
361 ksttsltsss tsgssdkvya hqmvrtdsre qkldaflqpl skplssqpqa ivtedktdis
421 sgrarqqdee mlelpapaev aaknqslegd ttkgtsemse krgptssnpr krhredsdve
481 mveddsrkem taactprrri inltsvlslq eeineqghev lremlhnhsf vgcvnpqwal
541 aqhqtklyll nttklseelf yqiliydfan fgvlrlsepa plfdlamlal dspesgwtee
601 dgpkeglaey iveflkkkae mladyfslei deegnliglp llidnyvppl eglpifilrl
661 atevnwdeek ecfeslskec amfysirkqy iseestlsgq qsevpgsipn swkwtvehiv
721 ykalrshilp pkhftedgni lqlanlpdly kvferc
//
Revised: October 24, 2001.
