Herpes

什麼是Herpes virus?  

  Herpesviruses屬於很常見的一種病毒,目前已發現的約有一百種,存在於許多不同的生物體中。全部種類均屬於Herpesviridae。Herpes virus雖然種類繁多,但他們基本形式是相似的,例如他們感染宿主的機制。目前所知道的Herpes virus可分為三類,alpha, beta and gamma herpesviruses,如下表:

Alpha herpesviruses Beta herpesviruses Gamma herpesviruses
Herpes simplex virus type 1 (HSV-1)
Cytomegalovirus (CMV) Epstein-Barr virus (EBV)
Herpes simplex virus type 2 (HSV-2) Human herpesvirus type 6 (HHV-6) Human herpesvirus type 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus)
Varicella zoster virus (VZV) Human herpesvirus type 7 (HHV-7)

  由於Herpes virus種類如此繁多,故研發它們共同的抑制劑相信可以有巨大的市場。所以Boehringer Ingelheim才會下手去研發它的抑制劑。

Herpes Simplex Virus

   
Herpes virus會引起什麼疾病?  
  目前已知Herpes virus所會引起的疾病主要分佈在皮膚和生殖器。其病徵如下:  
  • Epstein-Barr virus, which causes infectious mononucleosis (also known as ‘mono’ and ‘glandular fever’);

↑Adolescent girl with infectious mononucleosis.

  • Varicella zoster, which causes chickenpox and shingles;
↑Typical rash of chickenpox in an adult.
↑Typical rash of chickenpox in an adolescent.
↑Typical rash of chickenpox in an adult.
↑Typical herpes zoster rash.
  • Herpes simplex virus type 1, the cause of cold sores;

↑Typical blisters associated with cold sores due to HSV.

  • Herpes simplex virus type 2, the most common cause of genital herpes.
 
  雖然Herpes所引起的疾病對一般人而言並不會致命,但是對於自體免疫疾病的病人,如AIDS病人,此病是有可能會奪去他們生命的。而且,雖然此病沒有致病的憂慮,但在現代人的眼中,得了庖疹應該是會想要花錢去治好的;而自體免疫的病人更是必須要長期服用這些藥物。所以相信Anti-Herpes的藥是有一定之市場價值的。  

  

 

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