Protein kinase C phosphorylation site

In vivo, protein kinase C exhibits a preference for the phosphorylation of serine or threonine residues found close to a C-terminal basic residue [1,2]. The presence of additional basic residues at the N- or C-terminal of the target amino acid enhances the Vmax and Km of the phosphorylation reaction.

-Consensus pattern: [ST]-x-[RK]
                              [S or T is the phosphorylation site]
-Last update: June 1988 / First entry.

[ 1] Woodget J.R., Gould K.L., Hunter T. Eur. J. Biochem. 161:177-184(1986).
[ 2] Kishimoto A., Nishiyama K., Nakanishi H., Uratsuji Y., Nomura H., Takeyama Y., Nishizuka Y.
J. Biol. Chem. 260:12492-12499(1985).
{END}