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ATP + D-HEXOSE <=> ADP + D-HEXOSE 6-PHOSPHATE

Comment(s):

• D-GLUCOSE, D-MANNOSE, D-FRUCTOSE, SORBITOL AND D-GLUCOSAMINE CAN ACT AS ACCEPTORS.
• ITP AND DATP CAN ACT AS DONORS.
• THE LIVER ISOENZYME HAS SOMETIMES BEEN CALLED GLUCOKINASE.

Human Genetic Disease(s):
HEMOLYTIC ANEMIA DUE TO HEXOKINASE DEFICIENCY; MIM:235700.

Cross-Reference(s):

• Biochemical Pathways; map number(s): B6, C6
• PROSITE: PDOC00370 .
• EMP/PUMA: 2.7.1.1.
• WIT: 2.7.1.1.
• KYOTO UNIVERSITY LIGAND CHEMICAL DATABASE: 2.7.1.1.
• SWISS-PROT:
  

  P27595, HXK1_BOVIN;  P19367, HXK1_HUMAN;  P17710, HXK1_MOUSE;
  P05708, HXK1_RAT  ;  Q09756, HXK1_SCHPO;  P52789, HXK2_HUMAN;
  O08528, HXK2_MOUSE;  P27881, HXK2_RAT  ;  P50521, HXK2_SCHPO;
  P52790, HXK3_HUMAN;  P27926, HXK3_RAT  ;  P04806, HXKA_YEAST;
  P04807, HXKB_YEAST;  Q05810, HXKH_HUMAN;  P52791, HXKH_MOUSE;
  P17711, HXKH_RAT  ;  P35557, HXKP_HUMAN;  P52792, HXKP_MOUSE;
  P17712, HXKP_RAT  ;  Q42525, HXK_ARATH ;  P33284, HXK_KLULA ;
  Q02155, HXK_PLAFA ;  Q26609, HXK_SCHMA ;  P50506, HXK_SCHOC ;
  

If you would like to retrieve all the SWISS-PROT entries referenced in this entry, click here.

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