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Electrostatic calculations show a pronounced basic-charge distribution at the membrane-anchor end, or C-terminus, of the synaptic fusion complex. When the four-helix-bundle coalesce in to a complex immediately before fusion, the cumulative electrostatic potential may promote membrane fusion by affecting both membrane surfaces due to the opposite charge of the complex and membranes.
This charge distribution further confirms the fusion mechanism between SNAREs and synaptic membranes.