Shieh-Te Tan (Ph.D., Univ. of Nebraska-Lincoln , 1982)

1. Studies on the radiation-resistant bacterium Deinococcus radiodurans: mutagensis, DNA repair, cell division control, gene cloning.
2. Screening Chinese medicine for radiation sensitizers useful in cancer radiotherapy.

Representative publications

• Chou, F.I., and S. T. Tan. (1990). Manganese(II) induces cell division and increases in superoxide dismutase and catalase activities in an aging deinococcal culture. J. Bacteriol. 172:2029-2035.
• Chou, F. I., and Tan , S. T. (1991). Salt-mediated multicell formation in Deinococcus radiodurans, J. Bacteriol. 173:6184-6193.
• Lin, C. L., Lin, C. S., and Tan, S. T. (1995). Mutations showing specificity for normal growth or Mn(¢º)-dependent post-exponential-phase cell division in Deinococcus radiodurans. Microbiology 141:1707-1714
• Lin, C. L., and Tan, S.T. (1996). Isolation and characterization of a noval Deinococcus radiodurans mutant abnormally susceptible to mutation induction by UV , r-ray , and mitomycin C. Int. J. Radiat, Biol. 69: 496-502.
• Tan. S.T., and C.L. Chen. Further characterization of a novel Deinococcus radiodurans mutant abnormally susceptible to radiation mutagenesis and gene recombination. (To be submitted)
• Tan, S.T., and P.L. Hsu. Cell synchronization and cell cycle-dependent radioresistance in Deinococcus radiodurans. (To be submitted)
• Tan, S. T. et al. A novel cell volume mutant of Deinococcus radiodurans. (To be submitted)
• Yang, F.S., Chen, Y.L., Chang, F.R., Wu, Y.C. and S. T. Tan. Isolation and characterization of a novel anticancer drug THKM-X. (To be submitted)